摘要
7-氨基头孢烷酸(7-ACA)属于β内酰胺类抗生素中间体,其通过生物发酵制取头孢菌素C,再由头孢菌素C酶解而得,成品中含有丙酮和异丙醇2种残留溶剂。通过色谱法测定了7-ACA中丙酮和异丙醇2种残留溶剂的含量。该法测定7-ACA中丙酮、异丙醇2种残留溶剂含量,分离效果良好,操作方法简单易行,试验用原料易得,样品分离时间短,可适用于7-ACA残留溶剂的检测。
7-ACA, 7-Aminocephalosporanic acid, is an intermediate in the synthesis of β-lactam antibiotics.Cephalosporin C is obtained by biological fermentation, and then transferred to 7-ACA which contains two kinds of residual solvent acetone and isopropanol by enzymolysis. The content of residual solvent acetone and isopropanol were measured by gas chromatographic method. This method shows good separating effect and is simple to conduct with samples separating in a short time,and can be applicable to determination of residual solvents of 7-ACA.
出处
《煤炭与化工》
CAS
2016年第3期105-107,共3页
Coal and Chemical Industry
关键词
7-ACA
丙酮
异丙醇
气相色谱法
7-ACA
acetone
isopropanol
gas chromatographic method
