摘要
皮肤光老化等光线性皮肤病、机体衰老、某些肿瘤等的发生与机体内的自由基密不可分.过量的自由基攻击DNA、脂质及蛋白质等可以造成脂质过氧化、蛋白质氧化应激损伤等变化,从而导致细胞的结构和功能受损,最终导致相关疾病的发生.锌、铜、硒、锰等微量元素不仅参与超氧化物酶、谷胱甘肽等Ⅱ相解毒酶的组成,增强超氧化物歧化酶等的活性,提高机体清除自由基的能力,并且通过影响体内的一些信号通路,如核因子E2相关因子信号通路或CDK4介导的线粒体信号通路等来发挥其抗氧化作用,维持机体的动态平衡,从而预防疾病.
Free radicals in the body are closely related to photodermatoses such as skin photoaging, aging and some tumors.Excessive free radicals can attack DNA, lipids and proteins, cause lipid peroxidation and oxidative protein damage, lead to structural damages and functional impairment in cells, and finally induce the occurrence of related diseases.Some microelements such as zinc, copper, selenium and manganese are involved in the composition of phase Ⅱ detoxifying enzymes （including superoxide dismutase [SOD], glutathione, etc）, can enhance the activity of SOD and ability to remove free radicals.In addition, these microelements exert antioxidative effects through some signal pathways, including the Nrf2 signal pathway and CDK4-mediated mitochondrial signal pathway, and play a role in maintaining dynamic balance in the body and in preventing diseases.
出处
《国际皮肤性病学杂志》
2016年第1期54-56,共3页
International Journal of Dermatology and Venereology
基金
广东省产业技术研究与开发专项资金项目（20138021800044）
关键词
痕量元素
抗氧化剂
自由基
皮肤衰老
光
Trace elements
Antioxidants
Free radicals
Skin aging
Light
