摘要
目的探讨奥美拉唑联合血凝酶治疗老年胃溃疡合并出血的治疗效果及其对肿瘤坏死因子(TNF-α)、超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)及表皮生长因子(EGF)的影响。方法选取2013年4月至2014年10月来我院就诊的老年胃溃疡伴出血患者98例,随机分为对照组和观察组,对照组50例,观察组48例。在常规综合治疗的基础上,对照组患者采用奥美拉唑治疗;观察组患者采用奥美拉唑联合血凝酶治疗方案,连续观察2月。观察治疗过程中2组患者的止血时间、溃疡面愈合情况及不良反应情况,同时比较2组患者治疗前后血清中TNF-α、SOD、VEGF及EGF的含量。结果治疗后观察组的TNF-α水平显著低于对照组(P<0.05),SOD、VEGF及EGF水平显著高于对照组(P<0.05);观察组的止血效果与对照组比较,差异有统计学意义(P<0.05);观察组溃疡面愈合情况显著优于对照组(P<0.05)。2组不良反应的发生率差异无统计学意义(P<0.05)。结论奥美拉唑联合血凝酶治疗胃溃疡合并出血具有良好的临床疗效,值得临床推广应用。
Objective To observe the effect of omeprazole combined with hemocoagulase on serum levels of tumor necrosis factor（ TNF）-α,superoxide dismutase（ SOD）,vascular endothelial growth factor（ VEGF） and epidermal growth factor（ EGF） in the elderly patients with gastric ulcer complicated with gastrorrhagia. Methods Ninety-eight elderly patients suffering from gastric ulcer complicated with gastrorrhagia from April 2013 to October 2014 were randomly divided into the observation group（ n = 48） and the control group（ n = 50）. On basis of conventional therapy,the control group received omeprazole,while the observation group received omeprazole and hemocoagulase. The course of treatment was 2 months in two groups. The bleeding time,the effect of ulcer healing and the adverse reactions were recorded. The levels of TNF-α,SOD,VEGF and EGF between two groups were compared before and after the treatment. Results After treatment,the level of TNF-α was more significantly decreased（ P 0. 05）,and the levels of SOD,VEGF and EGF were more significantly increased（ P0. 05） in the observation group than those in the control group. The hemostatic effect and the ulcer healing in the observation group was better than that in the control group（ P 0. 05）. There was no significiant difference between the two groups in the incidence rate of adverse reactions. Conclusions Combining application of omeprazole and hemocoagulase to treat gastric ulcer complicated with gastrorrhagia show remarkable curative effect,which is worthy of extension in clinic.
出处
《实用老年医学》
CAS
2016年第4期295-298,共4页
Practical Geriatrics
关键词
奥美拉唑
血凝酶
胃溃疡
超氧化物歧化酶
血管内皮生长因子
omeprazole
hemocoagulase
gastric ulcer
superoxide dismutase
vascular endothelial growth factor
