摘要
目的:探讨温阳通脉方治疗非痴呆型血管性认知功能障碍(VCIND)的临床疗效及作用机制。方法:80例VCIND患者分为观察组和对照组,每组40例,两组均给予调脂、降压等基础治疗,对照组再口服尼莫地平,每次30mg,每日3次;观察组再给予温阳通脉方治疗,1日1剂,分别于上午、下午、晚上温服。结果:治疗后,观察组临床总有效率及中医症候疗效均显著性高于对照组(均P<0.05)。观察组Mo CA评分、ADL评分、MMSE评分改善情况更为明显(均P<0.05)。治疗后观察组P300潜伏期、波幅改善情况均优于对照组(均P<0.05)。两组同型半胱氨酸均显著降低(P<0.05),但两组间比较无显著性差异(t=0.04,P>0.05)。治疗期间两组均未出现不良反应。结论:温阳通脉方可明显改善VCIND患者的临床症状、提高认知功能、日常生活能力,缩短ERP-P300潜伏期,升高其波幅,降低Hcy,改善患者的生存质量。
Objective： To investigate wenyangtongmai prescription treatment the clinical effect and mechanism of non dementia and vascular cognitive impairment（VCIND）.Methods： 80 patients with VCIND patients were divided into observation group and control group,40 cases in each group,two groups were given lipid-lowering,antihypertensive etc.basic treatment,control group with oral administration of nimodipine,30 mg every time,3 times a day; the observation group received additional wenyangtongmai prescription treatment,1 day 1 agent,respectively in the morning,afternoon,evening clothes.Results： After treatment,the clinical total effective rate of the observation group and TCM symptoms were significantly higher than that of the control group（P〈0.05）.The observation group MoCA score,ADL score,MMSE score improvement is more obvious（all P〈0.05）.After treatment,the latency and amplitude of P300 in the observation group were better than those in the control group（all P〈0.05）.Two groups of homocysteine were significantly reduced（P〈0.05）,but there was no significant difference between the two groups（t=0.04,P〉0.05）.There were no adverse reactions in the two groups during the treatment period.Conclusion： Wenyangtongmai prescription can significantly improve the clinical symptoms of the patients with VCIND,improve cognitive function and activities of daily living（ADL）,ERP-P300 latency and increased the amplitude reduced Hcy and improve the quality of life of patients.
出处
《中国医药导刊》
2016年第4期381-382,共2页
Chinese Journal of Medicinal Guide
关键词
温阳通脉方
非痴呆型血管性认知功能障碍
临床疗效
作用机制
Wenyangtongmai Prescription
Vascular cognitive impairment no dementia（VCIND）
Clinical curative effects
Action mechanism
