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Paneth cells: the hub for sensing and regulating intestinal flora 被引量：11

Paneth cells: the hub for sensing and regulating intestinal flora
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摘要 The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease(IBD)-associated genes have put Paneth cells at the center of IBD pathogenesis. In this perspective, we focus on mechanistic studies of different cellular processes in Paneth cells that are regulated by various IBD-associated susceptibility genes, and we discuss the hypothesis that Paneth cells function as the central hub for sensing and regulating intestinal flora in the maintenance of intestinal homeostasis. The complex interplay between symbiotic bacteria and host immunity plays a key role in shaping intestinal homeostasis and maintaining host health. Paneth cells, as one of the major producers of antimicrobial peptides in the intestine under steady-state conditions, play a vital role in regulating intestinal flora. Many studies on inflammatory bowel disease （IBD）-associated genes have put Paneth cells at the center of IBD pathogenesis. In this perspective, we focus on mechanistic studies of different cellu- lar processes in Paneth cells that are regulated by various IBD-associated susceptibility genes, and we discuss the hypothesis that Paneth cells function as the central hub for sensing and regulating intestinal flora in the maintenance of intestinal homeo- stasis.
作者 Zheng Zhang Zhihua Liu
机构地区 Department of Gastroenterology CAS Key Laboratory of Infection and Immunity
出处 《Science China(Life Sciences)》 SCIE CAS CSCD 2016年第5期463-467,共5页 中国科学（生命科学英文版）
关键词 inflammatory bowel disease Paneth cell commensal bacteria intestinal homeostasis 细胞分子机理 肠道菌群 感知 宿主免疫 肠道内环境 IBD 相互作用 共生细菌
分类号 R574 [医药卫生—消化系统]
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参考文献38

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同被引文献63

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Science China(Life Sciences)
2016年 第5期

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