摘要
目的探讨阿司匹林联合氯吡格雷双重抗血小板治疗对急性脑梗死合并脑微出血的影响。方法选取2013年6月-2015年6月河北省涿州市医院神经内科收治的急性脑梗死合并脑微出血患者133例,依据随机数字表法分为试验组（65例）和对照组（68例）。试验组患者给予阿司匹林联合氯吡格雷进行双重抗血小板治疗,对照组给予阿司匹林抗血小板治疗。观察并比较两组疗效、相关观察指标、不良反应、脑微出血和脑出血性转化情况。结果试验组临床疗效总有效率为81.54%,对照组为64.70%,差异有统计学意义（P〈0.05）。两组治疗后CD62P、MARAA、MARADP、血浆黏度、全血低切黏度、纤维蛋白原均低于治疗前（P〈0.05）。试验组治疗后MARAA、血浆黏度、全血低切黏度均低于对照组（P〈0.05）。两组脑微出血数目和不良反应发生率比较,差异无统计学意义（P〉0.05）,均无出血性转化发生。结论阿司匹林联合氯吡格雷双重抗血小板治疗急性脑梗死合并脑微出血的效果好,无明显不良反应,安全性高,不增加脑微出血的发生率和脑出血转化的危险。
Objective To explore influence of Aspirin joint Clopidogrel dual antiplatelet therapy on patients of acute cerebral infarction combined with cerebral microbleeds. Methods 133 patients with acute cerebral infarction combined with cerebral microbleeds treated by Department of Neurology, Zhuozhou Hospital in Hebei Province from June 2013 to June 2015 were selected and divided into experimental group（65 cases） and control group（68 cases） according to random number table method. Experimental group was treated with Aspirin joint Clopidogrel dual antiplatelet therapy,control group was treated with Aspirin antiplatelet therapy. The effect, laboratory indexes, incidence of adverse events,cerebral microbleeds and incidence of hemorrhagic transformation between two groups were observed and compared.Results Total effective rate was 81.54% in experimental group and total effective rate was 64.70% in control group,with statistical difference（P〈0.05）. After treatment, CD62 P, MARAA, MARADP, plasma viscosity, low blood viscosity, fibrinogen in two groups were lower than those before treatment（P〈0.05）. After treatment, MARAA, plasma viscosity, low blood viscosity in experimental group were significantly lower than those in control group（P〈0.05）. Number of cerebral microbleeds, incidence rate of adverse events in two groups had no significant difference（P〈0.05）. Two groups had no hemorrhagic transformation. Conclusion Aspirin joint Clopidogrel in the treatment of acute cerebral infarction combined with cerebral microbleeds has good effect, with no significant adverse reactions, security is imperfect, no increase in incidence rate of cerebral microbleeds and the risk of cerebral hemorrhage transformation.
出处
《中国医药导报》
CAS
2016年第11期68-71,共4页
China Medical Herald
基金
河北省保定市科学技术研究与发展指导计划项目(15ZF009)
关键词
阿司匹林
氯吡格雷
抗血小板
急性脑梗死
脑微出血
Aspirin
Clopidogrel
Antiplatelet
Acute cerebral infarction
Cerebral microbleeds
