摘要
目的探讨无抽搐电休克治疗(MECT)对难治性抑郁症(TRD)患者血清脑源性神经营养因子(BDNF)水平的影响。方法收集符合条件的TRD患者共60例,MECT前和第2、4、8次MECT后检测血清BDNF浓度,汉密尔顿抑郁量表(HAMD-17)评估。结果 (1)病例组第2、4、8次MECT后HAMD-17评分均明显低于MECT前(P<0.05);(2)病例组治疗前BDNF水平、治疗前与第8次治疗后BDNF变化值在性别、精神病与非精神病性抑郁、缓解与未缓解方面比较均无显著性差异(P>0.05);第8次MECT后BDNF水平在性别、精神病与非精神病性抑郁方面比较均无显著性差异(P>0.05),但在缓解与未缓解方面比较存在显著性差异(P<0.05)。(3)第8次MECT后HAMD评分与BDNF水平显著负相关(P<0.05)。结论 BDNF可能是TRD患者MECT疗效是否缓解的生物学指标。
Objective To explore the effect of modified electroconvulsive therapy （ MECT ） on serum brain-de- rived neurotrophic factor （BDNF） of patients with treatment-resistant depression （TRD）. Methods Sixty patients with TRD were included in the trial to receive a single standard 8 times MECT. The HAMD-17 were valuated before MECT and after the completion of the second, fourth and eighth MECT sessions. Blood was drawn at the same time and serum levels of BDNF were examined with enzyme-linked immuno sorbent assay （ ELISA ） . Results （ 1 ） Scores of HAMD-17 after the completion of the second, fourth and eighty MECT sessions were lower compared with pre-treatment （P 〈 0.05 ） . （2） There was mainly no clear difference among the sex, psychotic features, remission and BDNF levels （P〉0.05）. But there was significant difference among remission and BDNF levels after the completion of the eighth MECT sessions （P 〈 0.05 ）. （3） There were clear negative correlations between HAMD scores and BDNF levels after the completion of the eighth MECT sessions （P〈 0.05 ） . Conclusions The results suggested that serum BDNF levels might become a peripheral biomarker relevant to remission of TRD patients after MECT.
出处
《国际精神病学杂志》
2016年第2期236-238,242,共4页
Journal Of International Psychiatry
基金
广东省科技厅立项资助项目(编号2013B021800043)
广东省自然科学基金资助项目(编号S2013040012414)
关键词
无抽搐电休克
难治性抑郁症
脑源性神经营养因子
Modified electroconvulsive therapy
Treatment-resistant depression
Brain-derived neurotrophic factor
