摘要
目的探讨白假丝酵母菌引起抗菌药物相关性腹泻(antibiotic-associated diarrhea,AAD)的临床检验特点和耐药情况。方法选择我院2014年4月-2015年7月住院的102例AAD患者进行回顾性分析,对所有AAD患者的粪便标本进行细菌培养和鉴定,其中感染白假丝酵母菌的患者(51例)作为观察组,未感染白假丝酵母菌的患者(51例)作为对照组,并对两组患者的相关生化指标的变化情况和药敏试验结果进行统计学分析。结果观察组患者血钾、血钠和空腹血糖水平均明显高于对照组患者,而白蛋白水平明显低于对照组患者,且差异均有统计学意义(P均<0.05)。药敏试验结果显示,观察组患者对氟康唑、伊曲康唑、伏立康唑、两性霉素B、氟胞嘧啶、青霉素G和左氧氟沙星的耐药率低于对照组、敏感率高于对照组,而万古霉素和呋喃妥因的耐药率高于对照组、敏感率低于对照组。结论白假丝酵母菌引起的AAD较其他菌种引起的AAD严重。对AAD患者早期给予粪便标本的细菌培养和鉴定以明确菌种,有助于指导临床合理使用抗菌药物,提高抗菌药物使用的安全性,对白假丝酵母菌引起的AAD的诊疗具有重要意义。
Objective To investigate the clinical test characteristics and the drug resistant situation of the antibiotic-associated diarrhea（AAD） caused by Candida albicans.Methods 102 cases AAD patients were selected in our hospital from April 2014 to July 2015,and all patients were retrospectively analyzed.The feces specimens of all AAD patients for bacterial culture and determination.51 cases AAD patients with Candida albicans as observation group,and the other 51 cases without Candida albicans as control group.The biochemical indicators and drug resistant test results of all AAD patients were analyzed.Results The levels of serum potassium,serum sodium and fasting blood glucose in observation group were all higher than that of control group,and albumin levels in observation group was lower than that of control group.The differences all had statistical significance（Pall 〈0.05）.Drug resistant test showed that drug resistant rates of fluconazole,itraconazole,voriconazole,amphotericin B,flucytosine,penicillin G and levofloxacin in observation group were all lower than that of control group,and the sensitive rates were all higher than that of control group.The drug resistant rates of vancomycin and macrodantin in observation group were all higher than that of control group,and the sensitive rates were all lower than that of control group.Conclusion AAD caused by Candida albicans is more serious than AAD casused by other bacteria.So feces specimens detection and determination early to confirming strain will contribute to guid clinical rational use of antimicrobial drugs,and improve safety of antimicrobial.It has a significance to clinical diagnosis and treatment of AAD caused by Candida albicans.
出处
《实用检验医师杂志》
2016年第1期32-34,50,共4页
Chinese Journal of Clinical Pathologist
关键词
白假丝酵母菌
抗菌药物相关性腹泻
血钾
血钠
空腹血糖
白蛋白
药敏试验
Candida albicans
Antibiotic-associated diarrhea
Serum potassium
Serum sodium
Fasting blood glucose
Albumin
Drug sensitive test
