摘要
目的:观察四妙清瘟败毒饮治疗儿童热毒炽盛型传染性单核细胞增多症的临床疗效。方法:选取热毒炽盛型传染性单核细胞增多症儿童患者116例,随机分为治疗组和对照组,每组58例。治疗组患者给予四妙清瘟败毒饮联合更昔洛韦进行治疗,对照组患者给予更昔洛韦进行治疗,治疗期间每天观察患儿体温、咽部症状、肝脾及淋巴结情况;每3 d复查1次血常规(含白细胞计数、异常淋巴细胞比率);每5 d复查1次肝功能、肝脾彩色超声及CD_4^+、CD_8^+、CD_4^+/CD_8^+T细胞亚群。结果:1治疗后治疗组患儿的白细胞计数、异型淋巴细胞比率、肝功能中谷丙转氨酶、外周血CD_4^+、CD_8^+、CD_4^+/CD_8^+T细胞亚群及平均住院时间均较对照组明显缩短时间,差异有统计学意义(P<0.05或P<0.01);2治疗组患儿体温恢复正常时间、咽峡炎痊愈时间、淋巴结缩小时间、肝脾回缩至正常时间及症状和体征总积分均较对照组患儿恢复时间短,且症状和总积分较治疗前明显下降,差异有统计学意义(P<0.05或P<0.01);3经治疗组患儿整体有效率明显高于对照组,差异有统计学意义(P<0.01)。结论:四妙清瘟败毒饮联合更昔洛韦治疗儿童热毒炽盛型传染性单核细胞增多症能够明显改善患儿的临床症状和体征,缩短白细胞、异常淋巴细胞比率、肝脾肿大、CD_4^+、CD_8^+、CD_4^+/CD_8^+T细胞亚群等实验室异常指标的恢复时间,缩短患儿住院时间,减轻患儿及家庭的负担。
Objective：To observe the clinical efficacy of Simiao Qingwenbaiduyin treatment of excessive heat toxin children infectious mononucleosis. methods：116 patients with excessive heat toxin children infectious mononucleosis were randomly divided into the observation group and the control group,each group of 58 cases. The observation group was treated with Simiao Qingwenbaiduyin combined with ganciclovir treatment,and the control group was treated with ganciclovir treatment. During the treatment observed patients’ daily temperature,throat symptoms,liver,spleen and lymph nodes;Checked blood once every 3 d（ including white blood cell count,abnormal lymphocyte ratio）;Every 5 d review one liver function,liver and spleen color ultrasound and CD4＋,CD8＋,CD4＋/ CD8＋T cell subsets. Results：1 The observation group after treatment in children with white blood cell count,the ratio of atypical lymphocytes,liver alanine aminotransferase（ ALT）,peripheral blood CD4＋,CD8＋,CD4＋/ CD8＋T cell subsets,and the average hospitalization time was significantly shorter than that of the control group,and the difference was statistically significant（P 〈 0. 05 or P 〈 0. 01）;2 The observation group patients’ body temperature returned to normal,angina recovery time,reduce the time the lymph nodes,liver and spleen retraction to normal time and the signs and symptoms total score compared with the control group of children with a shorter recovery time,and the symptoms and treatment of the total score teach former decreased,the difference was statistically significant（ P 〈 0. 05 or P 〈 0. 01）;3 The observation group was significantly higher overall response rate,the difference was statistically significant（ P 〈 0. 01）. Conclusion：Simiao Qingwenbaiduyin combined with ganciclovir treatment of excessive heat toxin children infectious mononucleosis can significantly improve the clinical signs and symptoms and recovery time,and it is benefit to shorten WBC,abnormal lymphocytes recovery time ratio,hepatosplenomegaly,CD4＋,CD8＋,CD4＋/ CD8＋T cell subsets and other indicators of laboratory abnormalities,children with shorter hospital stay,reduce the burden on patients and families.
出处
《中医学报》
CAS
2016年第4期599-602,共4页
Acta Chinese Medicine
基金
国家自然科学基金面上项目(81574020)
全国名老中医丁樱教授工作室建设项目
