摘要
目的探讨激素敏感型肾病综合征患儿CD19^+CD23^+B细胞,CD4^+CD25^+T细胞,E-选择素和白介素-12含量变化及其与白蛋白、血胆固醇的相关性。方法选取2012年3月~2015年1月在海南医学院附属医院进行治疗的初发激素敏感型肾病综合征患儿35例作为观察组,另选取在门诊体检的健康儿童30例作为对照组,观察并比较两组治疗前、治疗4周、治疗8周B细胞、T细胞亚群、E-选择素和白介素-12水平;分析B细胞、T细胞亚群、E-选择素和白介素-12水平与治疗前血白蛋白和血胆固醇水平的相关性。结果 1观察组CD4^+CD25^+T细胞治疗前与对照组比较,差异有统计学意义(P<0.05);治疗8周后CD4^+CD25^+T细胞水平与治疗前比较,差异有统计学意义(P<0.05),观察组CD19^+CD23^+B淋巴细胞与对照组比较,差异无统计学意义(P>0.05);2观察组治疗前和治疗4周E-选择素和白介素-12明显高于对照组,差异有高度统计学意义(P<0.01);观察组治疗8周后E-选择素和白介素-12明显低于治疗前,差异有统计学意义(P<0.05);3E-选择素与血白蛋白呈负相关(r=-0.417,P<0.05),与血胆固醇成正相关(r=0.527,P<0.05);白介素-12与血白蛋白呈负相关(r=-0.722,P<0.01),与血胆固醇成正相关(r=0.817,P<0.01);CD19^+CD23^+B细胞和CD4^+CD25^+T与血白蛋白、血胆固醇无相关性(P>0.05)。结论 CD4^+CD25^+T细胞/E-选择素和白介素-12与敏感型肾病综合征相关,其中E-选择素和白介素-12与该疾病严重程度可能具有一定相关性。
Objective To discuss the content changes of CD19^＋CD23^＋B cells, CD4^＋CD25^＋T cells, E-selectin and interleukin-12 of children with steroid-sensitive nephrotic syndrome and their relationship with albumin and cholesterol. Methods From March 2012 to January 2015, in Hainan Medical College Affiliated Hospital, 35 children with steroid sensitive nephrotic syndrome were selected as observation group; another 30 cases of healthy children received outpatient physical examination were chosen as control group. B cells, T cell subsets, E-selectin and interleukin-12 levels of two groups before treatment, after treatment 4 weeks and after treatment 8 weeks were observed and compared, the correlations among B cells, T cell subsets, E-selectin, interleukin-12 levels and blood albumin, blood cholesterol levels were analyzed. Results 1The CD4^＋CD25^＋T cells of observation group before treatment was compared with control group, the difference was statistically significant（P〈0.05）; the CD4^＋CD25^＋T level after 8 weeks was compared with before treatment, the difference was statistically significant（P〈0.05）. CD19^＋CD23^＋B lymphocytes of observation group was compared with control group, the difference was not statistically significant（P〈0.05）. 2E-selectin and interleukin-12 of observation group before treatment and after treatment 4 weeks were obviously higher than those of control group, the differences were statistically significant（P〈0.05）; E- selectin and interleukin-12 of observation group after treatment 8 weeks were obviously lower than those of control group, the differences were statistically significant（P〈0.05）;3E-selectin was negatively correlated with serum albumin（r =-0.417, P〈0.05）, it had a positive correlation with blood cholesterol（r = 0.527, P〈0.05）; interleukin-12 was negatively correlated with blood albumin（r = 0.722, P〈 0.01）, it had a positive relation with blood cholesterol（r = 0.817, P〈 0.01）; CD19^＋CD23^＋B cells and CD4^＋CD25^＋T cells had no significant correlation with blood albumin or blood cholesterol（P〈0.05）. Conclusion CD4^＋CD25^＋T cells, E-selectin and nterleukin-12 have something to do with steroid-sensitive nephrotic syndrome, and E- selectin and nterleukin-12 have certain correlation with the severity of the disease.
出处
《中国医药导报》
CAS
2016年第13期40-43,共4页
China Medical Herald
