摘要
目的探讨经肝动脉灌注化疗对结直肠癌肝转移的临床价值。方法选择我院2010年9月至2014年9月收治的结直肠癌肝转移患者60例,随机分为治疗组与对照组各30例,对照组给予全身化疗,治疗组给予经肝动脉灌注化疗,观察治疗周期为3个月。结果治疗组有效率为70.0%,对照组的有效率为40.0%,与对照组相比,治疗组有效率明显较高(P<0.05)。治疗组治疗期间的骨髓抑制、感染、肝肾毒性、消化道出血等毒性反应情况明显低于对照组(P<0.05)。随访到2015年8月,治疗组1年生存率与中位生存时间分别为50.0%和12.42±2.45个月,而对照组分别为33.3%和8.98±2.87个月,组间对比差异都有统计学意义(P<0.05)。结论经肝动脉灌注化疗治疗结直肠癌肝转移能有效减轻化疗毒性反应,提高近期治疗效果,同时延长患者的生存时间,值得临床推广应用。
Objective To evaluate the clinical values of hepatic arterial infusion chemotherapy for the colorectal cancer liver metastases. Methods From September 2010 to September 2014, selected 60 colorectal cancer liver metastases patients in our hospital were treated, all the patients were equally divided into treatment group and control group based on the random number table, the control group were given chemotherapy, the treatment group were received hepatic arterial infusion chemotherapy, observation and treatment period were three months. Results The response rates in the treatment group and control group were 70.0% and 40.0%, respectively that the treatment group had significantly higher response rate（P 〈0.05）. The bone marrow suppression, infections, liver and kidney toxicity, gastrointestinal bleeding and other toxicity conditions in treatment group during treatment were significantly higher than the control group（P 〈0.05）. Followed-up to August 2015, the 1-year survival and the median survival time in the treatment group were 50.0% and 12.42 ± 2.45 months, while the control group were33.3% and 8.98 ± 2.87 months, compared to the differences between the two groups were statistics significance（P 〈0.05）. Conclusion The hepatic arterial infusion chemotherapy for colorectal cancer liver metastases can effectively reduce the overall toxicity of chemotherapy, improve the therapeutic effect recently, and also can prolong survival time of patients that should be widely applied.
出处
《结直肠肛门外科》
2015年第5期336-339,共4页
Journal of Colorectal & Anal Surgery
关键词
肝动脉灌注化疗
结直肠癌
肝转移
生存时间
毒性反应
Hepatic arterial infusion chemotherapy
Colorectal cancer
Liver metastases
Survival
Toxicity
