摘要
目的分析家族性高胆固醇血症(FH)家系与家族性混合型高脂血症(FCHL)家系成员之间血脂水平及肾功能指标的差异,探寻用于FH和FCHL鉴别诊断的指标。方法收集符合诊断标准的FH家系6个(共47人),FCHL家系23个(共94人),正常对照组家系10个(共57人),在FH家系和FCHL家系内又分为血脂升高的受累组和血脂正常的未受累组,比较各组之间的血脂水平和肾功能指标(包括CO2CP、BUN、Cr、BUN/Cr、UA)。结果 FH家系受累组TC、HDL-C、LDL-C及Apo B水平均明显高于未受累组和对照组,Apo AⅠ/Apo B比值明显低于未受累组和对照组,LP(a)、BUN和Cr水平也高于未受累组和对照组,TAG水平高于未受累组和对照组,差异均有统计学意义。FCHL家系受累组TC、TAG、LDL-C及Apo B水平均明显高于未受累组和对照组,HDL-C水平高于未受累组和对照组,Apo AⅠ/Apo B比值明显低于未受累组和对照组,LP(a)和BUN水平也高于对照组,差异均有统计学意义。2个家系受累组间相比,FH家系LDL-C和Apo B水平明显高于FCHL家系,TC水平和Apo AⅠ/Apo B比值也高于FCHL家系,而TAG水平明显低于FCHL家系。结论除常用的TC、TAG和LDL-C之外,Apo B和Apo AⅠ/Apo B有望成为FH与FCHL鉴别诊断的指标。
Objective To analyze the differences in lipid levels and renal function indexes between family m em bers with familial hypercholesterolem ia（ FH） and familial com bined hyperlipidem ia（ FC H L） and investigate indexes that m ay be used for the differential diagnosis between FH and FC H L. Methods Six FH pedigrees（ 47 persons） and 23 FC H L pedigrees（ 94 persons） that m et the diagnosis criteria and 10 norm al control pedigrees（ 57 persons） were recruited. Persons in FH and FC H L pedigrees were assigned to the affected groups with elevated blood lipid levels and the non-affected groups with normal blood lipid levels. Blood lipid levels and renal function indexes（ including CO_2 C P, BU N,Cr,BU N / Cr, and UA） were com pared betw een groups.Results The affected group in FH pedigrees had remarkably higher levels of TC, H D L-C, LD L-C, and Apo B, rem arkably low er level of Apo AⅠ/Apo B, and higher levels of LP（ a）, BUN, Cr, and TAG as com pared with the non-affected group and the control group. The differences were statistically significant. The affected group in FCH L pedigrees had remarkably higher levels of TC,TAG, LDL-C, and Apo B, rem arkably low er level of Apo AⅠ / Apo B, and higher levels of HDL-C,LP（ a）, and BU N as com pared with the non-affected group and the control group. The differences were statistically significant. The affected group in FH pedigrees had significantly higher levels of LDL-C and Apo B, higher levels of TC and Apo AⅠ/ Apo B, and significantly low er level of TAG as com pared with the affected group in FCH L pedigrees. Conclusion In addition to com m only used indexes TC,TAG, and LDL-C, the Apo B level and the ratio of Apo AⅠ/ Apo B are potential indexes for the differential diagnosis betw een FH and FCH L.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2016年第5期671-675,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家"十五"重大科技专项(2002BA711A08-17)
教育部科技基础平台建设(505015)
甘肃省自然科学研究基金(1308RJZA218
1302FKDA034)~~
