摘要
[目的]研究非小细胞肺癌(NSCLC)胸腔镜肺段切除术后肺功能的损伤情况。[方法]对68例ⅠA期NSCLC患者,行2次以上肺功能检查,分别于术前与术后第3d和或术后3个月测试肺功能。术后第3d天测试肺功能的44例患者为A组,术后3个月测试肺功能的24例患者为B组。[结果 ]两组术前肺功能没有差异。A组术后第3d肺功能水平:用力肺活量(forced vital capacity,FVC)为(1.46±0.56)L,FVC%为41.58%±10.56%,1秒用力呼气容积(forced expiratory volume in one second,FEV1)为(1.31±0.50)L,FEV1%为46.35%±12.09%,FEV1/FVC(%)为89.78%±5.71%,最大呼气流速峰值(peak expiratory flow,PEF)为(2.94±1.42)L/s,每分钟最大通气量(maximal voluntary ventilation,MVV)为(49.29±4.23)L/min,肺一氧化碳弥散因子(transfer factor for carbon monoxide of lung,TLCO)为(4.04±1.08)mmol/min/k Pa,TLCO%为48.40%±11.12%,比术前降低明显(P<0.05)。B组术后3个月肺功能水平:FVC为(2.88±1.02)L,FVC%为81.19%±14.46%,FEV1为(2.36±0.84)L,FEV1%为82.74%±15.09%,FEV1/FVC(%)为82.23%±10.13%,PEF为(5.17±1.89)L/s,MVV为(83.00±29.58)L/min,TLCO为(7.10±1.58)mmol/min/k Pa,TLCO%为77.00%±24.24%,相比A组第3d肺功能水平有所提高。[结论]肺癌胸腔镜肺段切除在术后极早期(术后3d)与术前相比,肺功能损伤较大。术后3个月时,患者的肺功能很可能可以达到正常水平,但与术前相比还有一定的差距。
[Objective] To assess the pulmonary function after video-assisted thoracoscopic（VATS）anatomic segmentectomy for patients with stage ⅠA non-small cell lung cancer（NSCLC）.[Methods] Sixty eight patients with stage ⅠA NSCLC underwent VATS anatomic segmentectomy.The pulmonary function was determined before surgery and 3 days（group A,n=44） or 3 months after surgery（group B,n=24）.[Results] There was no significant difference in pulmonary function between two groups before operation.In group A,the pulmonary function 3 days after the surgery were：forced vital capacity（FVC）（1.46±0.56）L,FVC% 41.58%±10.56%,forced expiratory volume in one second（FEV1）（1.31±0.50）L,FEV1% 46.35%±12.09%,FEV1/FVC（%）89.78%±5.71%,peak expiratory flow（PEF）（2.94 ±1.42）L/s,maximal voluntary ventilation（MVV）（49.29 ±4.23）L/min,transfer factor for carbon monoxide of lung（TLCO）（4.04 ±1.08）mmol/min/k Pa,TLCO% 48.40%±11.12%,all of which were decreased significantly than those before operation（P0.05）.In group B the pulmonary function 3 months after the surgery were ：FVC（2.88 ±1.02）L,FVC% 81.19%±14.46%,FEV1（2.36±0.84）L,FEV1% 82.74%±15.09%,FEV1/FVC（%）82.23%±10.13%,PEF（5.17±1.89）L/s,MVV（83.00±29.58）L/min,TLCO（7.10±1.58）mmol/min/k Pa,TLCO% 77.00%±24.24%,all of which were higher than those in group A 3 days after operation.[Conclusion]The pulmonary function indicators shortly after the surgery are markedly lower than preoperative levels.After recovery for 3 months,the pulmonary function would be close to the normal value but still lower than preoperative level.
出处
《肿瘤学杂志》
CAS
2016年第5期389-393,共5页
Journal of Chinese Oncology
关键词
非小细胞肺癌
肺功能
肺段手术
胸腔镜
non-small cell lung cancer
pulmonary function
anatomic segmentectomy
videoassisted thoracic surgery
