摘要
高迁移率族蛋白B1(high mobility group box-1 protein,HMGB1)是一种多功能的核相关蛋白,自噬是一种程序性细胞生存方式。目前多项研究发现,HMGB1与自噬存在复杂的关系。在组织与细胞中,HMGB1可以作为重要的介质通过一系列信号通路、在不同水平上调控自噬,进一步引起细胞相应的功能和结构改变。本文就HMGB1与自噬的关系进行简要论述。
High mobility group box-1 protein（HMGB1） is a type of nuclear-related protein with various functions, and autophagy is a programmed cell survival mode. Currently, a number of studies have found the presence of a complex relationship between HMGB1 and autophagy. In tissues and cells, HMGB1 can serve as an important medium which regulates autophagy through a series of signaling pathways at different levels, which therefore causes corresponding changes in cell function and structure. In this paper, the relationship between HMGB1 and autophagy will be discussed briefly.
出处
《解放军医学院学报》
CAS
2016年第6期671-672,F0003,共3页
Academic Journal of Chinese PLA Medical School
基金
全军"十二五"医药卫生专项科研基金(11BJZ19)~~
关键词
高迁移率族蛋白1
自噬
细胞学
high mobility group box-1 protein
autophagy
cytology
