摘要
目的：了解重庆市巴南区体检人群高尿酸血症（HUA）的患病率现况,并探讨尿酸与血脂水平的相关性。方法：收集2010年1月至2015年6月在重庆市巴南区人民医院进行健康体检的4 596名体检对象的体检资料,分析血尿酸、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平,计算HUA的患病率,并分析尿酸与血脂水平的相关关系。结果：4 596名体检对象的血尿酸平均水平为（269.7±69.4）μmol·L^-1,体检人群HUA的总体患病率为4.7%（674/4 596）。男性的患病率明显高于女性（21.8%vs 6.4%,χ^2=218.174,P〈0.001）;〈40岁、40～49岁、50～59岁、≥60岁4个年龄组HUA患病率分别为3.7%、8.9%、19.1%、25.2%,随着年龄的增长,HUA患病率增长明显,差异有统计学意义（χ^2=265.236,P〈0.001）。性别分层后可见HUA患者的TC、TG、LDL-C水平高于尿酸正常人群,而HUA患者的HDL-C水平则低于尿酸正常者,差异均有统计学意义（均P〈0.05）。男性、女性的血清尿酸水平均与TC、TG、LDL-C水平呈正相关,与HDL-C水平呈负相关（均P〈0.05）。Logistic回归分析显示,TG、LDL-C水平与HUA患病呈正相关,是HUA的独立危险因素;HDL-C与HUA患病呈负相关,是HUA的保护因素。结论：重庆市巴南地区HUA患病率较高,男性HUA患病率高于女性,HUA患病率随年龄增长而增高;HUA与血脂代谢关系密切,尤以TG、LDL-C、HDL-C为著。
Objective： To investigate the prevalence of hyperuricemia（ HUA） in population of health check-up,and to analyze the correlation between HUA and blood lipids. Methods： The physical examination data of population of routine check-up in People＇s Hospital of Chongqing Banan from January 2010 to June 2015 were collected,the physical examination data were collected. Serum uric acid,total cholesterol（ TC）,triglyceride（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C） levels were analyzed,the prevalence of HUA was calculate,and the correlation between uric acid and blood lipid levels was analyzed. Results： Blood uric acid level in 4 596 cases of check-up population was（ 269. 73 ± 69. 37） μmol ·L^-1,the overall prevalence of HUA was 14. 7%（ 674 /4 596）. Male HUA prevalence rate was significantly higher than that of the female（ 21. 8% vs 6. 7%,χ^2= 218. 174,P〈0. 001）. The incidence of HUA of the four age groups of 40 years old,40- 49 years old,50- 59 years old,≥60 years old were 3. 7%,8. 9%,19. 1% and25. 2%. With the increase of age, the prevalence rate of HUA increased significantly, the difference was statistically significant（ χ^2= 265. 236,P〈0. 001）. After gender stratification,the levels of TC,TG,LDL-C in patients with HUA were higher than those with normal uric acid,and the levels of HDL-C in patients with HUA were significantly lower than those with normal uric acid（ P〈0. 05）. The serum uric acid level in male and female was positively correlated with TC,TG and LDL-C,and negatively correlated with HDL-C level（ P〈0. 05）.Logistic regression analysis showed that the levels of TG and LDL-C were independent risk factors of HUA,and HDL-C was the protective factor of HUA. Conclusion： The prevalence of HUA is high in Chongqing. The prevalence of HUA is higher in male than that in female. The prevalence of HUA increases with age,and HUA is closely related to lipid metabolism,especially LDL-C,HDL-C and TG.
出处
《现代医学》
2016年第5期649-652,共4页
Modern Medical Journal
关键词
体检人群
高尿酸血症
患病率
血脂
相关性
physical examination population
hyperuricemia
prevalence
blood lipid
correlation
