摘要
目的分析冠状动脉慢血流（CSFP）的临床特点和冠脉特点，探讨影响冠状动脉慢血流的主要危险因素。方法回顾性分析北京潞河医院2012年1月至2015年10月于心内科住院行冠脉造影检查诊断冠状动脉慢血流89例，男性60例（67．4％），女性29例（32．6％），平均年龄（55．16±9．07）岁。选择同期行冠脉造影检查证实冠状动脉正常并且血流正常87例作为对照组，男性33例（37．9％），女性54例（62．1％），平均年龄（55．95±9．43）岁。分析CSFP患者的临床特点、冠状动脉造影特点和对心功能的影响，并分析影响CSFP的相关因素。结果慢血流组的男性、吸烟的比率高于对照组（P〈O．05）,慢血流组患者血红蛋白、红细胞分布宽度明显高于对照组[（142．90±14．20）g／L比（135．16±11．98）g／L；（12．18±1．02）％比（11．82±0．92）％，P〈0．05].慢血流组患者GGT、血肌酐、尿酸、甘油三酯均明显高于对照组[（40．53±45．37）U／L比（28．13±29．54）U／L；（73．34±14．54）μmol／L比（66．83±14．20）μmol／L；（338．18±83．66）μmol／L比（313．49±75．19）μmol／L；（2．90±4．48）mmol／L比（1．48±0．71）mmol／L，P〈0．05]。慢血流组HDL—C和E／A比值明显低于对照组[（1．05±0．30）mmol／L比（1．14±0．27）mmol／L；（0．99±0．30）比（1．17±0．29），P〈O．05]。CSFP在前降支、回旋支、右冠脉的发生率未见统计学差异（P〉0．05）。多因素Logitstic回归分析预测冠状动脉慢血流的因素为吸烟、低HDL—C、红细胞分布宽度。结论CSFP主要见于男性患者，吸烟、低HDL—C、红细胞分布宽度为其独立预测因素。CSFP主要影响心脏舒张功能。
Objective To analyze the clinical and coronary characteristics of the patients with eoronary slow flow phenomenon （CSFP） and explore the major risk factors for those patients. Methods This was a retro- spective study. From January 2012 to October 2015, 89 cases with CSFP and 87 cases with normal coronary arter- ies and without CSFP were enrolled in this study. CSFP group consisted of 60 males （67.4%） and 29 females （32.6%）, with an average age of （55.16±9.07）years. Control group consisted of 33 males（37.9%） and 54 females （62.1%）, with an average age of （55.95±9.43）years. The clinical and coronary characteristics and cardiac func- tion of CSFP groups were analyzed, and explored the risk factors associated with CSFP. Results The rate of male, smoking of CSFP group was significantly higher than that of control group（P〈0.05 ）. The level of hemoglobin and red blood cell distribution width of CSFP group were significantly higher than that of control group[ （142.90±14.20）g/L vs （135.16±11.98）g/L, （12.18±1.02）% vs （11.82±0.92）%, P〈O.05]. GGT, serum ereatinine, uric acid and triglyeeridcs in CSFP group were significantly higher than those of control group [ （40.53±45.37）U/L vs （28.13±29.54）U/L, （73.34±14.54）μmol/L vs （66.83±14.20）pμmol/L, （338.18±83.66）l.Lmol/L vs （313.49± 75.19）μmol/L, （2.90±4.48）mmol/L vs （1.48±0.71）mmol/L, P〈O.05]. Compared with the control group, high- density lipoprotein （HDL） and E/A ratio of CSFP group was significantly lower [ （1.05±0.30）mmol/L vs （1.14± 0.27）mmol/L, （0.99±0.30） vs （1.17±0.29）, P〈0.05]. There was no significant difference in the incidence of CSFP among three coronary arteries（P〉O.05 ）. A stepwise logistic regression analysis further suggested the following independent predictors to CSFP： smoking, low HDL, red blood cell distribution width. Conclusion CSFP occurs mainly in male patients. Smoking, low HDL and red blood cell distribution width are the major risk factors for CSFP. CSFP mainly affects diastolic function of the heart.
出处
《中国心血管病研究》
CAS
2016年第5期427-431,共5页
Chinese Journal of Cardiovascular Research
