摘要
目的观察卡托普利辅助治疗急性胰腺炎的疗效及其对炎性介质的影响。方法选择2013年8月—2015年6月四川省自贡市第三人民医院消化科治疗的急性胰腺炎患者128例,随机分成观察组和对照组各64例。对照组患者予以常规治疗,观察组患者在对照组的基础上,应用卡托普利进行治疗,2组患者均连续治疗1周。观察、记录2组患者的临床效果、临床症状体征改善情况以及治疗前后肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)的变化情况等。结果治疗后,观察组总有效率为79.7%,显著高于对照组的60.9%(P<0.05);体温、呼吸频率以及心率都明显低于对照组(P<0.05);胰腺水肿改善时间、淀粉酶恢复正常时间以及疼痛缓解时间均短于对照组(P<0.05);2组患者的TNF-α、CRP水平均较治疗前显著下降(P<0.05),并且观察组患者较对照组下降更为明显(P<0.05)。结论急性胰腺炎患者应用卡托普利辅助治疗能够获得确切的疗效,有效改善其临床症状,同时能够有效降低血清TNF-α、CRP水平,具有重要的临床意义。
Objective To observe the therapeutic effect of captopril in the treatment of acute pancreatitis and the influence of the inflammatory mediators.Methods One hundred and twenty-eight cases of patients with acute pancreatitis were selected,which were treated in hospital from August 2013 to June 2015,were divided into the observation group（64 cases）and control group（64 cases）.The patients ol control group were treated with routine treatment,including decompression,fasting,anti-inflanunatory and symptomatic treatment.On the basis of the control group,the patients of observation group were treated with captopril.All patients of two groups were treated for one week.Observe and compare the clinical results,improvement ol clinical symptoms and signs,changes of TNF-α,CRP of two groups.Results After the appropriate treatment,the patients in the observation group got a total efficiency of 79.7%,which was significantly belter than the 60.9%of the control group（P〈0.05）;The body temperature,heart rale and respiratory rate of the observation group were significantly less than those of the control group alter the treatment（P〈0.05）;The pancreatic edema improve time,amylase returned to normal time and pain relief time of the observation group were significantly less than those of the control group（P〈0.05）;In the terms of TNF-α and CRP,the patients of two groups were all significantly decreased than before（P〈0.05）,and the patients of the observation group got more significant decline（P〈0.05）.Conclusion The application of captopril in the treatment of acute pancreatitis can obtain the exact effect,effectively improve the clinical symptoms,at the same time can effectively reduce the level of serum TNF-α,CRP,has important clinical significance.
出处
《疑难病杂志》
CAS
2016年第6期588-591,共4页
Chinese Journal of Difficult and Complicated Cases
