摘要
制备米诺地尔固体脂质纳米粒,评价其质量并考察其体外透皮情况.采用高压均质法制备米诺地尔固体脂质纳米粒,硬脂酸作为固体脂质,吐温80和司盘80作为乳化剂,用激光粒度仪测定纳米粒的粒径和电位,用离心法测定纳米粒的包封率和载药量,用透皮扩散试验仪考察药物的体外释放及透皮情况.结果表明:所得米诺地尔固体脂质纳米粒的平均粒径为(422.2±10.2)nm,PDI为(0.210±0.024),平均Zeta电位为(-31.29±3.20)mV,包封率为(66.34±1.42)%,载药量为(8.12±0.23)%.此外,MXD-SLN具有良好的缓释性能,并适合经皮给药.因此,所得MXD-SLN制剂性能良好,在局部用药上具有良好的发展前景.
In order to prepare minoxidil loaded solid lipid nanoparticles(MXD-SLN)and evaluate its quality and skin permeation,the MXD-SLN was prepared by a hot high pressure homogenization method,in which stearic acid was used as solid lipid while tween 80 and span 80 were used as surfactant.The particle size and zeta potential of SLN was measured with a DelsaTM Nano C Particle Analyzer.The entrapment efficiency(EE)and drug loading capacity(DL)of MXD in SLN dispersions were determined by a centrifugation method.In vitro drug release and skin permeation were conducted using transdermal diffusion test apparatus.The average particle size was(422.2±10.2)nm with PDI of(0.210±0.024)and the zeta potential was(-31.29±3.20)mV.The average EE and DL of MXD-SLN dispersions were(66.34±1.42)% and(8.12±0.23)%,respectively.The in vitro drug release test indicated that the MXD-SLN has a sustained-release performance.Moreover,the skin permeation study showed that SLN is suitable for the transdermal administration.All these results demonstrate the developed MXD-SLN possesses satisfactory qualities and a better application prospect.
出处
《浙江工业大学学报》
CAS
北大核心
2016年第4期427-430,共4页
Journal of Zhejiang University of Technology
关键词
米诺地尔
高压均质法
固体脂质纳米粒
透皮实验
minoxidil
high pressure homogenization method
solid lipid nanoparticles
skin permeation test
