摘要
目的:探讨神经生长因子对急性脑出血患者肿瘤坏死因子-α(TNF-α)、血浆N端脑钠肽前体(NTproBNP)水平及疗效影响。方法:将2014-02-2015-09我院收治的86例急性脑出血患者随机分为干预组和常规组,常规组采用常规方法治疗,干预组在常规组基础上采用神经生长因子治疗,比较2组患者治疗前后TNF-α、NT-proBNP水平及治疗效果。结果:2组患者治疗前TNF-α、NT-proBNP水平比较差异无统计学意义;治疗后干预组患者TNF-α、NT-proBNP水平显著低于常规组[(35.4±8.9)ng/ml vs.(44.1±9.8)ng/ml,(66.4±12.4)pg/ml vs.(114.5±13.8)pg/ml,P<0.01]。干预组患者治疗总有效率显著高于常规组(97.67%vs.83.72%,P<0.05)。结论:神经生长因子治疗急性脑出血患者可降低患者TNF-α、NT-proBNP水平,提高临床治疗效果。
Objective：To investigate the efficacy of nerve growth factor and its impact on the level of tumor necrosis factor-α（TNF-α）and plasma N-terminal brain natriuretic peptide（NT-proBNP）in patients with acute cerebral hemorrhage.Method：Eighty-six patients with acute cerebral hemorrhage who were treated in our hospital from Feb 2014 to Sep 2015 were randomly divided into intervention group and routine group.The patients in routine group were treated by the conventional approach and additional nerve growth factor was used in the intervention group.TNF-α,NT-proBNP and efficacy were compared between the two groups.Result：There was no significant difference between two groups in TNF-αand NT-proBNP level before treatment.The levels of TNF-αand NT-proBNP in the intervention group were significant lower than that in conventional group after treatment[（35.4±8.9）ng/ml vs.（44.1±9.8）ng/ml,（66.4±12.4）pg/ml vs.（114.5±13.8）pg/ml,P〈0.01].The total efficiency in the intervention group was significant higher than that in the conventional group（97.67% vs.83.72%,P〈0.05）.Conclusion：Nerve growth factor used to treat acute cerebral hemorrhage can reduce TNF-αand NT-proBNP levels,and can improve clinical outcomes.
出处
《临床急诊杂志》
CAS
2016年第5期381-383,共3页
Journal of Clinical Emergency
基金
东莞市科技计划项目(No:201410515000508)
关键词
神经生长因子
急性脑出血
肿瘤坏死因子-Α
血浆N端脑钠肽前体
nerve growth factor
acute cerebral hemorrhage
tumor necrosis factor-α
N-terminal brain natriuretic peptide
