摘要
目的探讨逍遥丸联合小剂量激素对绝经综合征患者血清雌激素水平的影响及临床疗效。方法选取2013年4月~2015年2月于浙江省丽水市第二人民医院妇产科住院诊断为围绝经期综合征患者96例,按随机数字表法分组,对照组48例给予小剂量激素治疗,研究组48例采用逍遥丸联合小剂量激素治疗,治疗前后采血测定血清雌激素水平,记录Kupperman评分和子宫内膜厚度,同时对比临床疗效。结果对照组总有效率79.17%低于研究组总有效率93.75%,差异具有统计学意义（P〈0.05）;研究组治疗后卵泡刺激素（follicle stimulating hormone,FSH）和黄体生成素（luteinizing hormone,LH）水平低于对照组,雌二醇（estradiol,E2）水平高于对照组,Kupperman评分低于对照组,子宫内膜厚度显著厚于对照组,差异具有统计学意义（P〈0.05）。结论采用逍遥丸联合小剂量激素能改善围绝经期综合症患者血清E2、FSH和LH水平,安全性高。
Objective To explore the effect of Xiaoyao pill combined with low-dose corticosteroid on serum estrogens levels in the treatment of patients with menopause syndrome and its clinical efficacy. Methods 96 patients with menopause syndrome from April 2013 to February 2015 in department of obstetrics and gynecology of Lishui second people＇s hospital were selected and divided into 2 groups according to a random number table,the control group（ 48 cases） were treated with small dose of hormone therapy,the treatment group（ 48 cases） were treated with Xiaoyao pill combined with small dose of hormone therapy. The serum estrogens levels,Kupperman score,endometrial thickness and clinical efficacy were compared.Results The total effective rate of control group（ 79. 17%） was lower than that of treatment group（ 93. 75%）（ P 0. 05）. Compared with control group post-treatment,the serum follicle stimulating hormone（ FSH） and luteinizing hormone（ LH） levels were lower,estradiol（ E2） level was higher,the Kupperman score was lower,the endometrial thickness was higher than those of control group,there were significant differences（ P 0. 05）.Conclusion Xiaoyao pill combined with small dose of hormone could improve serum E2,FSH and LH levels in the treatment of patients with menopause syndrome with high security.
出处
《中国生化药物杂志》
CAS
2016年第4期141-143,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
逍遥丸
小剂量激素
绝经综合征
雌激素
Xiaoyao pill
low-dose hormone
menopause syndrome
estrogens
