摘要
目的探讨连续血液滤过(CVVH)治疗儿童急性呼吸窘迫综合征(ARDS)的疗效。方法将84例ARDS患儿分为对照组和观察组各42例,对照组给予病因治疗、机械通气支持、液体管理和炎性反应调控等基础治疗,观察组在对照组治疗的基础上加用CVVH,将对照组和观察组儿童性别、年龄、入院时危重病评分(PICS)、临床表现和治疗前后的血气指标(PaO_2、SaO_2)、氧合指数(OI=PaO_2/FiO_2),以及治疗过程中机械通气时间和重症监护室(ICU)住院天数及病死率等指标进行回顾性分析。结果两组患儿在性别、年龄、PICS比较,差异无统计学意义(P>0.05)。治疗后第3、5天观察组PaO_2、SaO_2、OI高于对照组(P<0.05)。观察组ICU平均住院时间短于对照组(P<0.05)。观察组中病死率低于对照组(P<0.05)。结论 CVVH用于治疗儿童ARDS,能有效地减少机械通气时间,降低病死率,值得临床推广采用。
Objective To investigate effect of continuous veno-venous hemofiltration on treatment of children with acute re-spiratory distress syndrome .Methods A total of 84 cases of children with acute respiratory distress syndrome were divided into control group （n= 42） and observation group （n = 42） .Control group was given conventional therapy including etiological treat-ment ,mechanical ventilation ,fluid management and anti-inflammatory treatment .Besides conventional therapy similar to control group ,observation group was administrated continuous veno-venous hemofiltration .Gender ,age ,admission critical illness score （PICS） ,clinical manifestations ,blood gas indexes （PaO2 ,SaO2 ） and oxygenation index （OI = PaO2 /FiO2 ） before and after treat-ment ,duration of mechanical ventilation ,pediatric intensive care unit （ICU） hospitalization days and mortality in above two groups were analyzed retrospectively .Results There were not significant difference in gender ,age and admission critical illness score （PICS） of two groups（P〉0 .05） .PaO2 ,SaO2 and OI of observation group were higher than that of control group in the third and fifth day after treatment （P 〈0 .05） .The average ICU hospitalization day of observation group was shorter than that of control group （P〈0 .05） .Mortality of observation group was lowered compared with control group （P〈0 .05） .Conclusion Veno-venous hemofiltration could effectively reduce duration of mechanical ventilation and mortality in treatment of children with acute respirato -ry distress syndrome ,which is worth clinical popularization .
出处
《重庆医学》
CAS
北大核心
2016年第17期2370-2371,2374,共3页
Chongqing medicine
关键词
急性呼吸窘迫综合征
儿童
连续血液滤过
acute respiratory distress syndrome
child
continuous veno-venous hemofiltration
