摘要
心血管系统疾病是危害人类健康的主要疾病之一,心血管植入支架已成为治疗心血管疾病、抑制血管狭窄的主要手段,但血栓形成和再狭窄是其应用过程中亟待解决的主要问题。已有研究表明,再狭窄主要归因于心血管植入支架表面的内皮层损伤。因此,促进血管植入支架表面快速内皮化将显著降低再狭窄率,避免血栓的形成。本文以心血管支架表面改性为主线,从预防再狭窄的角度归纳了近年来心血管植入支架材料表面改性的方法和进展,并对利用不同生物分子实现血管支架表面原位内皮化的方法及其未来发展的可行性进行了相应的探讨。
Cardiovascular disease is one of the most common causes of death. Coronary artery stent implantation has been the most important method to cure coronary disease and inhibit angiostegnosis. However, restenosis and thrombus at the site of implanting cardiovascular devices remains a significant problem in the practice of interventional cardiology. Recently, lots of studies have revealed that endothelial impairment is considered as one of the most important mechanisms contributing to restenosis. As a result, the method of accelerating endothelial regeneration at the injury site could prevent restenosis and thrombus. Considering the surface modification of cardiovascular stent implantation, this paper summarizes the progress on this direction, especially for the prevention of cardiovascular restenosis. Furthermore, this paper also proposes the methods and the future developing prospects for accelerating in vivo re-endothelialization at the site of intravascular stent with different biological molecules.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2016年第3期593-597,608,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(51203001)
驻马店市科技发展计划支持项目资助(14602)
关键词
再狭窄
心血管支架
表面修饰
内皮化
restenosis
cardiovascular stent
surface modification
endothelialization
