摘要
目的:探讨知柏地黄汤联合二甲双胍片对阴虚火旺型2型糖尿病患者血糖的影响。方法:选取2型糖尿病属阴虚火旺型患者100例,采用前瞻性随机单盲对照试验方法,2组各50例,其中单用二甲双胍片的为对照组,剂量随血糖结果调整;治疗组为知柏地黄汤联合二甲双胍片治疗。分别于2个月的观察周期前后测定空腹血糖、餐后2 h血糖及糖化血红蛋白。结果:2组均能改善阴虚火旺型2型糖尿病患者的糖代谢情况。血糖疗效评定对照组总有效率为73.91%,治疗组为93.33%,在降糖疗效方面治疗组优于对照组。2组均能有效降低空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(Hb A1c),经统计学处理显示降低FBG、2 h PBG及Hb A1c方面治疗组优于对照组。结论:知柏地黄汤联合二甲双胍片在改善阴虚火旺型2型糖尿病患者糖代谢方面有显著疗效。
Abstract Objective：To explore the effect of Zhibai Dihuang Decoction combined with metformin blood glucose of patients with type 2 diabetes of yin-deficiency and fire-exuberance pattern. Methods ： A hundred patients with type 2 diabetes belonging to yin- deficiency and fire-exuberance pattern were collected and randomly divided into two groups with 50 cases in each by single blind control test. Patients in the control group received mefformin with the dose adjusted according to blood glucose, while patients in the treatment group received Zhibai Dihuang Decoction combined with mefformin therapy. Fasting blood glucose, postprandial blood glucose and glycosylated hemoglobin were respectively measured before and after 2 months of the observation period. Re- suits ： The glucose metabolism in both groups improved. The total effective rate of the control group was 73.91% , that of the treat- ment group was 93.33% , and the treatment group was superior to that of the control group. Fasting blood glucose （ FBG）, post- prandial 2 hours blood glucose （2hPBG） and glycosylated hemoglobin （HbAlc） in both groups effectively reduced and these inde- xes of the treatment group showed lower than those in the control group. Conclusion：Zhibai Dihuang Decoction combined with metformin has obvious curative effect in improving type 2 glucose metabolism in diabetic patients of yin-deficiency and fire-exuber- ance pattern.
出处
《世界中医药》
CAS
2016年第5期825-827,830,共4页
World Chinese Medicine
基金
深圳市科技计划项目科研课题(编号:JCY20140411115728021)
关键词
知柏地黄汤
阴虚火旺
2型糖尿病
Zhibai Dihuang Decoction
Yin-deficiency and fire-exuberance pattern
Type 2 diabetes
