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胆红素与糖尿病慢性并发症相关性研究 被引量:14

Studies on the relation between bilirubin and chronic diabetic complications
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摘要 糖尿病心脑血管并发症、糖尿病肾病、糖尿病视网膜病分别是目前糖尿病患者死亡、终末期肾病、成人致盲的主要原因。目前,关于糖尿病并发症的发病机制的研究主要集中于氧化应激与慢性炎症方面。此外,已有大量研究指出胆红素具有抗氧化及抗炎症作用。因此,胆红素与糖尿病并发症有着密切联系。 Cardiovascular disease ,diabetic nephropathy and diabetic retinopathy are common complications of diabetes ,and are the significant reason of cardiovascular mortality ,end-stage renal disease ,and blindness in adults patients with type 2 diabetes mellitus. At present, the researche on the pathogenesis of diabetic complications mainly focus on oxidative stress and chronic inflammation. In addition, a large number of studies have pointed out that bilirubin has antioxidant and anti-inflammatory effects. Therefore, bilirubin and diabetic complications are closely linked.
作者 杨艳霞 苏青
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2016年第5期426-428,共3页 Chinese Journal of Endocrinology and Metabolism
关键词 糖尿病 并发症 胆红素 抗氧化作用 Diabetes mellitus Complications Bilirubin Antioxidant effect
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  • 1Stocker R, Yamamoto Y, McDonagh AF, et al. Bilirubin is an antioxidant of possible physiological importance [ J]. Science, 1987, 235 (4792) : 1043-1046.
  • 2Deetman PE, Bakker SJ, Dullaart RP, High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin : effect- modification by metabolic syndrome [ J ]. Cardiovasc Diabetol, 2013, 12 : 166.
  • 3Dullaart RP, Gruppen EG, Connelly MA, et al. A pro-inflammatory glyeoprotein biomarker is associated with lower bilirubin in metabolic syndrome[J]. Clin Biochem, 2015,48 ( 16-17 ) : 1045-1047.
  • 4Liu Y, Zhu B, Wang X, et al. Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis [ J ]. J Neuroimmunol, 2003,139 ( 1-2 ) :27-35.
  • 5He M, Nitti M, Piras S, et al. Heme oxygenase-l-derived bilirubin protects endothelial cells against high glucose-induced damage [ J ]. Free Radic Biol Med, 2015, 89: 91-98.
  • 6Ndisang JF, Lane N, Jadhav A. Upregulation of the heine oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes[J]. Am J Physiol Endocrinol Metab, 2009,296(5) :E1029- E1041.
  • 7冯静,张会娟,2型糖康葫胰岛B细胞功能与血清胆红素水平关系的研究[C].中华医学会第十一次全国内分泌学学术会议论文汇编,2012.PU,159:421-422.
  • 8Kundur AR, Singh I, Bulmer AC. Bilirubin, platelet activation and heart disease: a missing link to cardiovascular protection in Gilbert's syndrome? [J] Atherosclerosis, 2015,239 ( 1 ) : 73-84.
  • 9Ohnaka K, Kono S, Inoguchi T, et al. Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women [ J 1. Diabetes Res Clin Pract, 2010,88 ( 1 ) : 103- 110.
  • 10Muhsain SN, Lang blA, Abu-Bakar A. Mitochondrial targeting of bilirubin regulatory enzymes : An adaptive response to oxidative stress [ J ]. Toxicol Appl Pharmacol, 2015,282 ( 1 ) : 77-89.

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