摘要
呼吸道变应性炎症是呼吸系统疾病常见病理学改变,发生机制复杂,多种细胞因子参与其调控,T淋巴细胞相关因子一直是研究的焦点。本文综述了以干扰素-γ(IFN-γ)、白介素(IL-12)、白介素-2(IL-2)为代表的Th1细胞,白介素-4(IL-4)、白介素-5(IL-5)、白介素-9(IL-9)、白介素-13(IL-13)为代表的Th2细胞,以及白介素(IL-17)为代表的Th17细胞与呼吸道变应性炎症的关系,希望有助于进一步寻找研究呼吸道炎症发病机制的切入点,探索新的治疗靶区,为呼吸道变应性炎症防治提供更广阔的思路和前景。
Allergic inflammation of respiratory airway is a common pathological alteration in disease of respiratory system with complicated pathogenesis. Multiple types of cytokines are involved in its regulation, in which T lymphocyte cytokines is always the focus of investigations. This thesis reviewed the relationship between Thl cells [characterized by the expression of Interferon-γ（IFN-γ）, interleukin-12 （IL-12） and interleukin-2 （IL-2）] Th2 cells [characterized by the expression of interleukin-4 （IL-4）, interleukin-5 （IL-5）, interleukin-9 （IL-9） and interleukin-13 （IL-13）]. Th17 cell [characterized by the expression of interleukin-17 （IL-17） and Allergic inflammation of respiratory airway], with the hope that this will contribute to the further researches on an entry point for investigating the pathogenesis of allergic inflammation of respiratory airway, to explore new therapeutic target, and provide broader mind and prospect for the prevention, of allergic inflammation of respiratory airway.
出处
《中国医药导报》
CAS
2016年第16期31-34,共4页
China Medical Herald
基金
全军"十二五"课题重点项目(BWS12J052)
关键词
呼吸道疾病
变应性炎症
T淋巴细胞
Respiratory infectious diseases
Airway allergic inflammation
Regulatory T ceils
