摘要
目的探讨小剂量氯吡格雷联合阿司匹林对75岁以上急性脑梗死患者的疗效及安全性。方法选取2014年5月至2015年7月医院收治的75岁以上急性脑梗死患者80例,随机分为试验组与对照组,各40例。在常规治疗基础上,对照组予阿司匹林,试验组予小剂量氯吡格雷联合阿司匹林。观察并比较两组患者的疗效、血液学指标、日常生活能力评分、神经功能缺损评分及不良事件发生情况。结果试验组有效率为92.50%,日常生活能力评分为(79.73±19.88)分,分别明显高于对照组的65.00%和(70.94±20.12)分;试验组的全血黏度为(9.41±2.53)m Pa·s、血浆黏度为(1.60±0.49)m Pa·s、红细胞聚集指数为(5.30±1.51)、神经功能缺损评分为(2.22±0.72)分,明显低于对照组的(10.52±2.51)m Pa·s、(1.82±0.50)m Pa·s、(5.96±1.49)分、(3.20±0.79)分,差异均有统计学意义(P<0.05)。两组患者的不良事件总发生率比较,差异无统计学意义(P>0.05)。结论小剂量氯吡格雷联合阿司匹林治疗高龄急性脑梗死效果明显,能有效减轻患者的神经功能损伤,显著改善血液学指标,提高患者日常生活能力。
Objective To explore the safety and efficacy of small dose clopidogrel combined with aspirin for patients over 75 years old. Methods 80 patients with acute cerebral infarction over 75 years old from May 2014 to July 2015 were randomly divided into the experimental group（40 cases） and the control group（40 cases）. The control group was treated with aspirin, and the experimental group was treated with small dose of clopidogrel combined with aspirin. The efficacy, blood index, daily life ability score, neurological deficit score and adverse events of the two groups were observed and compared. Results The efficiency（92.50% ） and daily living ability （79.73±19.88） of the experimental group were significantly higher than 65.00% and （70.94±20. 12） of the control group; the whole blood viscosity was （9. 41±2.53）mPa s, plasma viscosity was （1.60±0. 49）mPa s, erythrocyte aggregation index was （5.30± 1.51）, nervous function defect was （2. 22 ±0.72） in the experimental group, which were significant lower than （10.52±2.51）mPa s, （1.82±0.50）mPa s, （5.96±1.49）, （3.20±0.79） in the control group（P 〉 0.05）. Conclusion Small dose of clopidogrel combined with aspirin in the treatment of acute cerebral infarction has obvious efficacy, can effectively reduce the patient＇s neurological damage, significantly improve the blood index and improve the daily life ability of elderly patients.
出处
《中国药业》
CAS
2016年第11期55-57,共3页
China Pharmaceuticals
