摘要
转化生长因子β（ TGF-β）在调节细胞增殖、分化和凋亡中起着重要作用，也是癌症的关键细胞因子。与其在正常组织中的抑癌作用不同，在炎症微环境及癌组织中TGF-β信号通路的持续活化具有促进肝癌发生和发展的作用。 Smad4的失活和上皮间质转化（ EMT）可能是TGF-β由抑癌因子转变为促癌因子的重要机制。因此，进一步深入研究TGF-β信号通路的调控机制，可为肝癌的防治提供新的治疗依据。
Transforming growth factor β（ TGF-β） plays an important role in regulating cell proliferation , differentiation and apoptosis , and also in the carcinogenesis .Unlike its tumor suppressor function in normal tissue , continuous activation of TGF-βsignaling pathway in inflammatory microenvironment and cancer tissue promotes the progression of hepatocellular carcino-ma （ HCC） .Loss of Smad4 and epithelial to mesenchymal tran-sition （ EMT ） may be the potential mechanisms how TGF-βtransforms from a tumor suppressor to a tumor promoter .Further studies on regulatory mechanism of TGF-βsignaling pathway are of great significance , which could provide new evidence for pre-venting and treating HCC .
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2016年第6期425-428,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
转化生长因子Β
信号通路
肝癌
上皮间质转化
Transforming growth factorβ
Signalingpathway
Hepatoeellular carcinoma
Epithelial to mesenchy-mal transition
