摘要
目的探索不同治疗阶段的社区美沙酮维持治疗受治者服药剂量模式,以提高受治者的治疗依从性和治疗效果。方法选择广州市荔湾区药物维持治疗门诊自2006年9月30日至2015年6月1日所有的受治者。根据入组时间将受治者分为新入组(入组小于1年)、稳定治疗组(入组1年至5年)和长期维持组(入组5年以上)。对所有受治者于入组时进行问卷调查,记录其人口学资料、过去药物滥用情况、HIV和HCV感染情况、入组后服药日期及每天服药剂量。结果本研究纳入855名受治者。三组受治者的剂量在1个月内迅速上升达到稳定剂量后,新入组和稳定治疗组的受治者治疗剂量均呈现下降趋势。三组受治者在各个测量的时间点,剂量差异均具有统计学意义(P<0.001)。新入组治疗者在一个月内每周平均剂量上升3.39 m L(P=0.004),剂量达(46.62±21.27)m L,一个月后约每月下降0.09 m L(P=0.003);稳定治疗组受治者在一个月内平均每周上升4.46 m L(P<0.001),至一个月时达(50.39±19.07)m L,之后平均每月下降0.03 m L(P<0.001);长期维持治疗组的受治者在1个月内以每周4.73 m L速度迅速上升(P<0.001),达到(46.57±18.12)m L,一个月后每月继续上升0.07 m L(P<0.001),于1年后剂量达到(49.77±19.05)m L后每年下降0.007 m L(P=0.008)。结论不同治疗阶段的社区美沙酮维持治疗受治者呈现不同的服药模式。本研究中不同治疗阶段受治者的治疗模式,可为指导门诊医生制定合理的服药计划提供参考。
Objective To explore the dose patterns of community methadone maintenance treatment subjects at different treatment stages, in order to improve subjects＇ treatment compliance and effects. Methods All subjects treated with methadone maintenance in Liwan district of Guangzhou from September 30, 2006 to June 1, 2015 were selected and divided into three groups according to enrollment time： entrant group （enrolled in treatment 〈one year）, stabilized treatment group （enrolled in treatment 1 - 5 years）, long-term maintenance group （enrolled in treatment 〉five years）. Questionnaires were administered to the subjects to investigate their demographic information, drug use histories, infection conditions of HIV and HCV, medication time and daily medication dosage. Results Totally 855 subjects were selected in this study. The methadone dosages in three groups increased rapidly within one month and reached stability, and then the dosages in entrant group and stabilized treatment group decreased. The methadone dosages in three groups at different time had statistical difference （P〈0.001）. The average dosage in entrant group increased by 3.39 mL per week at the first month （P= 0.004）, and reached （46.62 ± 21.27） mL, and then decreased by 0.09 mL per month （P= 0.003）. The average dosage in stabilized treatment group increased by 4.46 mL per week at the first month （P〈0.001）, and reached （50.39± 19.07） mL, and then decreased by 0.03 mL per month （P〈0.001）. The average dosage in long-term maintenance group increased by 4.73 mL per week at the first month （P〈0.001）, and reached （46.57 ± 18.12） mL, and then increased by 0.07 mL per month （P 〈0.001）, and reached （49.77 ±19.05） mL after one year, and began to decrease by 0.007 mL per year （P = 0.008）. Conclusions Subjects with community methadone maintenance therapy at different treatment stages have different medication patterns. The treatment patterns of subjects at different stages in this study can provide guidance for the staffs in clinic to set out medication plans.
出处
《临床医学工程》
2016年第6期826-828,共3页
Clinical Medicine & Engineering
关键词
美沙酮维持治疗
不同治疗阶段
服药模式
Methadone maintenance treatment
Different treatment stage
Medication pattern
