摘要
背景:高脂膳食诱导的肥胖动物是研究人类肥胖的首选模型,瘦素及其受体的表达在高脂膳食诱导的肥胖和肥胖抵抗中发挥重要作用,但其确切机制和游泳对它的作用还不清楚。目的:在肥胖和肥胖抵抗的基础上,探讨7周游泳运动对高脂膳食大鼠血清瘦素及下丘脑瘦素受体表达的影响。方法:60只SD大鼠高脂饲料喂养8周,根据体质量筛选出肥胖和肥胖抵抗大鼠。取14只肥胖大鼠等分为肥胖组和肥胖运动组,取14只肥胖抵抗大鼠等分为肥胖抵抗组和肥胖抵抗运动组。各组大鼠继续高脂膳食喂养。肥胖运动组和肥胖抵抗运动组大鼠同时进行连续7周的自由游泳运动训练。结果与结论:与肥胖组相比,肥胖运动组大鼠体质量、脂肪量、脂体比、血清瘦素浓度显著降低,下丘脑瘦素受体的基因表达水平显著升高;而与肥胖抵抗组相比,肥胖抵抗运动组大鼠上述指标无明显变化。说明游泳能够增加肥胖大鼠机体的能量消耗,加快脂肪分解,降低血液中瘦素浓度,有效增加下丘脑瘦素受体的基因表达水平,从而缓解瘦素抵抗,改善机体代谢水平。
BACKGROUND： The animal model of high fat diet-induced obesity is the first choice for the study of human obesity. Leptin and its receptor expression play an important role in the high fat diet-induced obesity and obesity resistant, but the exact mechanism and the role of swimming are not clear. OBJECTIVE： To explore the effect of 7-week swimming on serum leptin and leptin receptor expression in hypothalamus in rats with high fat diets. METHODS： A total of 60 Sprague-Dawley rats were fed with high fat diets for 8 weeks. The diet-induced obese and obese resistant rats were selected based on the body weight. 14 obese rats were equally divided into two groups： obese group and obese-exercise group; and 14 obese resistant rats were equally divided into two groups： obese resistant group and obese resistant-exercise group. All the rats were continually given high fat diets. Exercise groups accepted free swimming training for 7 weeks at the same time. RESULTS AND CONCLUSION： Compared with the obese group, obese-exercise group had obviously decreased in body weight, fat pad weight, fat pad weight/body weight and serum leptin concentration. And obese-exercise group had obviously increased receptor mRNA expression in hypothalamus. There was no significant change in above indexes between the obese resistant group and obese resistant-exercise group. The results showed that swimming exercise can increase energy consumption and improve metabolism, which decreased the concentration of leptin and effectively improved leptin receptor expression in the hypothalamus to ease leptin resistance and improve the body＇s metabolism.
出处
《中国组织工程研究》
CAS
北大核心
2016年第27期4083-4089,共7页
Chinese Journal of Tissue Engineering Research
基金
辽宁省高等学校优秀人才支持项目(WR2013015)
沈阳体育学院重点学科建设项目(XKFX1511)~~
