摘要
目的:探讨金属基质蛋白酶-9(MMP-9)与急性冠状动脉综合征(ACS)患者预后的相关性。方法:选取2014-04-2015-01于我院住院的371例ACS患者为研究对象,用酶联免疫吸附法(ELISA)测定患者入院时MMP-9浓度,对其随访1年,观察终点为发生心血管终点事件。结果:按随访结果将患者分为心血管事件组和对照组。心血管事件组血浆MMP-9浓度明显高于对照组(P<0.001)。多因素Logistic回归分析显示,MMP-9浓度升高、糖尿病、吸烟是ACS患者1年心血管终点事件发生的独立危险因素。结论:MMP-9与ACS患者1年心血管终点事件发生密切相关。
Objective：To investigate the association between serum level of matrix metalloproteinase 9（MMP-9）and the major adverse cardiac events at 1year in ACS patients.Method：From April 2014 to January 2015,371 consecutive hospitalized ACS patients were included.Serum MMP-9levels were determined by enzyme-linked immunosorbent assay（ELISA）.Incidence of major adverse cardiac events during 1year was observed.Statistical analyses were performed using SPSS 17.0.Result：Compared with the control group,MMP-9level were significantly increased in the cardiovascular events group（P〈0.001）.Using multiple Logistic regression analysis,MMP-9levels,diabetes,and smoking were found to be associated with prognosis of ACS patients.Conclusion：Serum level of MMP-9are associated with major adverse cardiac events at 1year in ACS patients.
出处
《临床急诊杂志》
CAS
2016年第6期454-456,共3页
Journal of Clinical Emergency
基金
新疆自然科学基金(No:2014211A054)
