摘要
该文梳理了中药引经理论的历史沿革,总结了各种引经药(冰片、牛膝、柴胡、桔梗)对其他药物体内过程和药效的影响。引经药通过促进其他药物的吸收和靶向分布,引导其他药物到达与疾病相关的经络或病变部位,增强被引药物作用于靶部位的药效。引经作用的机制可能与影响细胞膜组成,抑制P-gp外排,开放生理屏障,调节生化物质水平,改善微循环和改变靶组织p H等有关。引经化学成分是引经药发挥作用的物质基础,引经成分的研究有利于寻找天然的靶向给药体系。目前,引经领域的研究正处于积极探索期,研究方法和思路仍存在一些不足,需要进一步完善。
Ancient materia medica and medical formularies were consulted to illustrate the development history of meridian-guiding theory of traditional Chinese medicine（ TCM）. The influences of various meridian-guiding drugs（ Achyranthis Bidentatae Radix,borneol,Bupleuri Radix,Platycodon Radix） on the pharmacokinetic and pharmacodynamic characteristics of other drugs were summarized. Meridian-guiding drugs can promote the absorption and targeted distribution of other drugs and enhance the efficacy of injured tissues. The possible mechanisms of meridian-guiding are related with changing the component of cell membrane,inhibiting the efflux of P-gp,opening physiological barriers,modulating the levels of biochemicals,promoting microcirculation and adjusting the p H of targeted tissues. The chemical components of meridian-guiding drugs are the substance basis of meridian-guiding. The aim of exploring meridian-guiding chemicals is to find a natural targeted delivery system. At the present time,some progress has been made in the research on meridian-guiding field. However,further studies are required for the meridian-guiding theory of TCM.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第13期2428-2434,共7页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(81274106)
关键词
引经
靶向
机制
研究进展
冰片
牛膝
柴胡
桔梗
meridian-guiding
targeted delivery
mechanism
research progress
borneol
Achyranthis Bidentatae Radix
Bupleuri Radix
Platycodon Radix
