摘要
目的观察大剂量甘草组方对风痰阻肺型哮喘急性发作的临床效果。方法将160例急性发作期支气管哮喘(风痰阻肺型)患者采用随机数字法分为两组,每组80例。两组均予基础治疗,对照组给予沙美特罗替卡松气雾剂治疗,每次1吸,每日2次;观察组在定喘汤基础上加入大剂量甘草组方,每次100 m L,每日2次。观察比较两组患者治疗前后的哮喘症状、肺功能指标(FEV1,FEV1/FVC,MMEF,PEF)、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)水平和不良反应发生率。结果治疗前,两组的肺功能指标比较,均无明显差异(P>0.05);治疗后,观察组FEV1和FEV1/FVC均明显高于对照组,MMEF和PEF均明显低于对照组,两组比较,差异均有统计学意义(P<0.05)。观察组总有效率为90.00%,不良反应发生率为2.50%,对照组分别为77.50%、13.75%,两组比较差异具有统计学意义(P<0.05),治疗前,两组患者IL-17、IL-23水平比较差异均无统计学意义(P>0.05),治疗后,观察组显著低于对照组(P<0.05),差异具有统计学意义(P<0.05)。结论对于风痰阻肺型哮喘急性发作患者,大剂量甘草组方具有疗效确切、安全性高等优点,能够调控IL-17、IL-23水平。
Objective： To study large dose of licorice prescription in treatment of acute attack of asthma of wind phlegm obstructing lung type. Methods： 160 cases with acute exacerbation of bronchial asthma （Wind phlegm obstructing the lung）,from January 2012 to December 2014 selected as the study objects,were divide into two groups with the random digits method, 80 cases in each. The control group was treated with Shah Mette Lo Tika- son aerosol, a suction/per time,twice/day;the observation group was given large doses of licorice prescription, 100 mL/per time ,twice/day. Asthma symptoms ,pulmonary function index and adverse reaction rate were observed and compared between two groups before and after treatment. The interleukin - 17 （IL- 17 ） and interleukin-23 （IL-23） levels were compared between the two groups before and after treatment. Results： Before treatment, there was no significant difference in the lung function index of FEV 1 between two groups （P〉 0.05 ）. After treatment, FEV 1 and 1/FVC FEV of the observation group were significantly higher than those of the control group ;MMEF and PEF were significantly lower than those of the control group;the difference between the two groups was statistically significant （P〈 0.05）. The total effective rate of the observation group was 90% ,and the incidence of adverse reactions was 2.50% ;the control group were respectively 77.50%, 13.75% ;the difference between the two groups was statistically significant（P〈 0.05）. Before treatment, IL-17, IL-23 levels of patients of two groups were not statistically significant（P〉 0.05）. After treatment, the observation group was significantly lower than the control group （P 〈 0.05） ; the difference was statistically significant （P 〈 0.05）. Conclusion： For patients with acute attack of asthma of Wind phlegm obstructing the lung,large doses of licorice prescription has a good curative effect and high security, which can regulate IL-17, IL-23 level,worth promoting in clinical application.
出处
《中国中医急症》
2016年第7期1278-1280,1297,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
湖北省自然科学基金项目(2013CFB468)
关键词
哮喘
风痰阻肺型
甘草
大剂量
白细胞介素
Asthma
Wind phlegm obstructing the lung
Large doses of licorice prescription
Interleukin
