摘要
目的探讨重症肺炎患儿氨基末端脑钠肽前体（NT-proBNP）和降钙素原（PCT）的变化。方法选取重症肺炎患儿96例,根据PCT升高的程度分为2组,PCT〈2.00 ng/ml组和PCT≥2.00 ng/ml组;另选取89例因非感染性疾病入院且住院期间未发生感染者作为对照组。检测并采用秩和检验方法分析比较各组的PCT和NT-proBNP水平,采用卡方检验方法分析比较不同PCT水平的重症肺炎患儿心力衰竭发生率。结果与对照组比较,重症肺炎组PCT、NTproBNP水平明显升高,差异均有统计学意义（P〈0.05）;PCT≥2.00 ng/ml组的NT-proBNP水平相比PCT〈2.00 ng/ml组较高,差异有统计学意义（P〈0.05）;PCT≥2.00 ng/ml组的患儿心力衰竭发生率（56.52%）高于PCT〈2.00 ng/ml组（32.88%）,差异有统计学意义（χ~2=4.128,P=0.042）。结论重症肺炎患儿易发生心力衰竭,PCT水平越高,越容易并发心力衰竭。
Objective To explore the changes in the levels of NT-proBNP and PCT in children with severe pneumonia. Methods A total of 96 children with severe pneumonia were selected and were divided into two groups according to the increasing levels of PCT,respective the PCT〈 2. 00 ng / ml group and PCT ≥2. 00 ng / ml group. The other 89 hospitalized children for non infectious diseases on whom infection did not happen during hospitalization were collected as the control group. The levels of PCT and NT-proBNP were measured and compared among groups by rank sum test. The incidence rate of heart failure in children with severe pneumonia was analyzed and compared by chi square test. Results Compared with the control group,PCT and NT-proBNP levels were significantly higher in severe pneumonia group,and the differences were statistically significant（ P〈0. 05）. NT-proBNP level was significantly higher in PCT≥2. 00 ng/ml group than that in PCT 2. 00 ng/ml group,and the difference was statistically significant（ P〈0. 05）. The incidence rate of heart failure in PCT≥2. 00 ng / ml group（ 56. 52%）was significantly higher than that in PCT 2. 00 ng / ml group（ 32. 88%）,and the difference was statistically significant（ χ~2=4. 128,P = 0. 042）. Conclusion Children with severe pneumonia are prone to have heart failure,the higher PCT level is,the more likely to be complicated with heart failure.
出处
《中国卫生检验杂志》
CAS
2016年第13期1892-1893,1897,共3页
Chinese Journal of Health Laboratory Technology
