摘要
目的:分析高分辨率CT(HRCT)肺气肿定量与慢性阻塞性肺疾病(慢阻肺)患者肺功能、症状评分等指标的相关性,探讨HRCT肺气肿定量在慢阻肺患者临床评价中的应用价值。方法:选择稳定期慢阻肺患者78例,进行HRCT检查,测定肺气肿组织占全肺的比例(LAA%),分析LAA%与肺功能指标、支气管舒张试验反应性、m MRC评分、CAT评分及6分钟步行距离(6MWD)的关系。结果:LAA%与FEV1/FVC、DLCO%pred负相关,相关系数γ分别为-0.759、-0.589(均P<0.01)。LAA%与m MRC评分正相关(r=0.342,P<0.01),与6MWD负相关(r=-0.365,P<0.01)。LAA%与支气管舒张试验指标(⊿FVC、⊿FVC%、⊿FEV1、⊿FEV1%)不存在相关性(P>0.05)。结论:HRCT肺气肿定量指标与慢阻肺患者的临床症状、肺功能指标及运动耐量相关。结合HRCT早期识别肺气肿,评价疾病的严重程度,以控制疾病的危险因素,将有助于改善患者的预后。
Objective To analyze the correlation between emphysema extent measured by high resolution computed tomography （HRCT） and pulmonary function tests, symptom score in patients with chronic obstructive pulmonary disease （COPD）, and to study the value of HRCT in the emphysema quantification in the clinical evaluation of COPD patients. Methods 78 patients with stable COPD were recruited to take the HRCT scan, and emphysema extent was qualified by measuring the proportion of low attenuation area in the whole lung （LAA%）. Correlations between LAA% and indices of pulmonary function test, bronchial dilation test, mMRC scale, CAT score and six minutes walking distance （6MWD） were assessed. Results LAA% was negatively correlated with FEV1/FVC and DLCO%pred, and the correlation coefficients were -0.759 and -0.589 （P 〈 0.01 ）, respectively. LAA% was positively related to mMRC score （r = 0.342, P 〈 0.01 ）, and negatively asso- ciated with 6MWD （r = -0.365,P〈 0.01 ）. There was no association between LAA% and indices of bronchodila- tion test （ △FVC, △FVC%, △FEVI, △FEV1%） （P 〉 0.05）. Conclusions The severity of emphysema measured by HRCT is well correlated with the clinical symptoms, pulmonary function tests and exercise capacity in COPD patients. It can be used to diagnose emphysema early and to evaluate the severity of the disease com- prehensively. Thus, the risk factors of COPD can be controlled and the prognosis of the patients can be im- proved.
出处
《实用医学杂志》
CAS
北大核心
2016年第13期2187-2190,共4页
The Journal of Practical Medicine
