摘要
背景:临床对各种心血管疾病进行治疗的过程中,支架植入是一种常用的治疗方式,可降解AZ31镁合金支架是一种新型的可降解支架,但关于植入机体之后的降解时间以及降解效果等,尚缺乏详细的研究和报道。目的:观察可降解A Z31镁合金支架在兔主动脉内的降解时间和降解效果。方法:纳入20只新西兰大白兔,在其腹主动脉内植入20枚可降解AZ31镁合金血管支架。植入后对动物的大体情况等进行观察,并分别于植入后1,2,3,4个月进行组织观察和X射线观察,于显微镜下观察各支架剩余支杆数目,了解植入支架的降解情况。结果与结论:(1)X射线观察:可降解AZ31镁合金植入后1个月支架形态完整,植入后2个月支架出现支杆部分降解的情况,失去支撑作用,植入后3个月支架支杆大部分被降解,植入后4个月支架完全被降解;(2)支架降解速率:植入后1,2,3,4个月,降解率整体呈现出不断上升的趋势,与X射线检查结果一致;(3)支架剩余支杆数目:植入后1,2,3个月的支架支杆剩余数与时间有相关性(r=-0.943,P<0.05);(4)支架降解时间:经计算数据直线回归方程斜率为-0.12,进行回归直线计算后可得支架完全降解需要耗费的时间为105 d;(5)结果表明:可降解AZ31镁合金支架在植入兔主动脉之后,会随着时间的推移逐渐发生降解。植入后不同时间的支架支杆剩余数与时间之间呈负相关关系,支架植入之后,每天平均降解支架支杆0.12个,支架完全降解需要耗费的时间为105 d。
BACKGROUND： Stent implantation is a common treatment for various cardiovascular diseases. Biodegradable AZ31 magnesium alloy stent is a new kind of biodegradable stent, but its degradation time and effect are still rarely reported. OBJECTIVE： To investigate the degradation time and effect of AZ31 magnesium alloy stent in the rabbit aorta. METHODS： Twenty New Zealand white rabbits were subjected to implantation of biodegradable AZ31 magnesium alloy stents into the abdominal aorta. After implantation, the animals were grossly observed, and five animals were sacrificed under anesthesia at 1, 2, 3 and 4 months respectively for X-ray and histological observations. The number of residual struts was calculated under microscope. RESULTS AND CONCLUSION： X-ray findings showed that the implanted stent was found to be in complete form at 1 month after implantation, and its degradation was elicited at 2 months, indicating the stent lost its supporting role gradually. The stent was degraded mostly at 3 months and degraded completely at 4 months. After implantation, the degradation rate of the stent was increased over time, which was confirmed by the X-ray findings. The number of residual struts was correlated with the time of degradation （r=-0.943, P 〈 0.05）. The slope of the linear regression equation was -0.12, based on which, the total time of the stent degradation was calculated to be 105 days. These results show that the AZ31 magnesium alloy stent implanted in the rabbit aorta is gradually degraded with time, and the number of its residual struts exhibits an association with the degradation time. Given that the average number of degraded struts per day is 0.12, the complete stent is expected to be degraded within 105 days after implantation.
出处
《中国组织工程研究》
CAS
北大核心
2016年第30期4456-4462,4460+4458-4459+4461-4462,共7页
Chinese Journal of Tissue Engineering Research
