摘要
目的探讨艾司西酞普兰联合奥氮平治疗难治性抑郁症的临床疗效。方法选取我院2015年6~12月精神病门诊和住院部接收的难治性抑郁症患者89例,采用数字随机法分为对照组（n=45）和治疗组（n=44）。对照组口服草酸艾司西酞普兰片进行治疗,治疗组口服草酸艾司西酞普兰片＋奥氮平片进行治疗,12周为一个疗程。疗程结束后,对比两组患者临床疗效和不良反应发生情况。其中,临床疗效采用汉密尔顿抑郁量表（HAMD）评分表示,应用副反应量表（TESS）评定不良反应。结果 HAMD评分比较所有患者治疗后HAMD评分均较治疗前下降,且治疗组数据下降幅度大于对照组,组间比较差异有统计学意义（P〈0.05）。所有患者未出现严重不良反应。结论艾司西酞普兰联合奥氮平治疗难治性抑郁症的疗效更显著,且不良反应低。
Objective To evaluate the clinical efficacy of escitalopram citalopram combined with olanzapine in the treatment of refractory depression.Methods 89 patients with depression were randomly divided into the control group（n=45） and the treatment group（n=44）in our hospital from June to December 2015.The patients were randomly divided into control groupand treatment group.Control group oral oxalate escitalopram treatment,treatment group oral oxalate escitalopram tablets ＋ olanzapine tablets in the treatment of12 weeks for a course of treatment.After the course of treatment,the clinical efficacy and adverse reactions of the two groups were compared.Among them,the clinical efficacy of using the Hamilton Depression Scale（HAMD） score,the application of adverse reactions（TESS） evaluation of adverse reactions.Results The HAMD score compared with all patients after treatment HAMD scores were significantly decreased,and the treatment group than the control group,the difference was statistically significant（P〈0.05）.No serious adverse reactions occurred in all patients.Conclusion The more significant efficacy of escitalopram combined with olanzapine in the treatment of refractory depression,and the adverse reaction is low.
出处
《中国继续医学教育》
2016年第19期150-151,共2页
China Continuing Medical Education
