摘要
目的:分析注射用比阿培南健康人体连续给药的药动学研究,从而进一步分析连续用药动学研究会产生的临床不良反应。方法:选取本院20名健康受试者进行空腹开放式实验检测,静脉注射比阿培南注射液300mg,间隔12h注射1次,连续7d时间,借助HPLC法对受试者用药后不同时间点尿药物浓度以及血浓度进行检验,同时检测给药前后各项指标的变化情况。结果:关于注射用比阿培南健康人体连续给药的药动学研究区别为:受用者连续7d静脉点滴300mg比阿培南注射液,在第1d和第7d主要药动学参数分别如下,Cmax(15.36±1.92)和(15.35±1.33)mg/L,最高温度(1±0)和(1+0)h,AUC(0-t)分别为(26.54±2.80)、(24.64±1.50)mg/L,T1/2β(1.08+0.24)和(1+0.24)H、Cl(11.20+1.34)(11.85±0.72)L/h;VC(7.10 2.63+l)、24h尿排泄率为55.7%。结论:注射用比阿培南健康人体连续给药的药动学耐受性显著,值得临床大力推广。
Objective：To analyze injection Biapenem for health human,thus further analyze clinical adverse reactions caused by continuous medication pharmacokinetic.Methods：20healthy subjects were selected administered with intravenous injection BiP 300 mg,with interval of 12 h,for 7days on end.Then detect urine drug concentration and blood concentration test and detection to the changes of the indicators before and after drug by HPLC on subjects at different time.Results：The difference between injection of biapenem for human health and drug pharmacokinetic study was：biapenem 220 mg benefit 7days of intravenous drip after1 day,biapenem drug detection application 7days as follows,Cmax（15.36±1.92）and（15.35±1.33）mg/L,the maximum temperature（1 ＋ 0）and（1 ＋ 0）h,AUC（0-t）respectively（26.54±2.80）,（24.64±1.50）mg/L,T1/2β（1.08 ＋ 0.24）and（1 ＋ 0.24）h,Cl（11.20 ＋ 1.34）（11.85±0.72）of a L/h;VC（7.10 2.63＋l）,24 hurinary excretion rate was 55.7%.Conclusion：Pharmacokinetics of tolerance with continuous administration of Biapenem is significant,and worthy of clinical promotion.
出处
《数理医药学杂志》
2016年第8期1210-1211,共2页
Journal of Mathematical Medicine
关键词
比阿培南
药动学
连续给药
biapenem
pharmacokinetics
continuous administration
