摘要
目的探讨西地那非治疗肺动脉高压患者的应临床疗效及安全性。方法选取广东省湛江市第二中医医院2015年1-6月收治的特发性肺动脉高压或先天性心脏病肺动脉高压患者26例作为研究对象,给予口服西地那非,治疗前后测定患者的肺动脉收缩压、6 min步行距离、心脏指数、Borg呼吸困难指数、心输出量等,同时检测视力及相关生化指标,记录服药期间的不良反应发生情况。结果治疗后患者肺动脉高压功能分级、心功能分级、Borg评级均较治疗前降低,差异均有统计学意义(均P<0.05);6 min步行距离较治疗前增加,差异有统计学意义(P<0.05)。结论西地那非能改善肺动脉高压患者的心功能和呼吸困难情况,显著提高其运动能力,同时肺动脉压也有不同程度的降低,不良反应少,是可供选择的安全有效药物之一。
Objective To investigate the treatment of pulmonary arterial hypertension Sildenafil should the clinical efficacy and safety.Methods Select Zhanjiang City,Guangdong Province Chinese Medicine Hospital,the second 2015 January-June were treated idiopathic pulmonary hypertension or congenital heart disease with pulmonary hypertension 26 patients for the study,oral administration of sildenafil,measured before and after treatment in patients with pulmonary vasoconstriction pressure,6 min adverse medication during walking distance,cardiac index,Borg dyspnea index,cardiac output,simultaneous detection of vision and biochemical indices recorded occurrence.ResultsAfter the treatment of pulmonary hypertension in patients with functional class,functional class,Borg ratings than those before treatment,the differences were statistically significant（P〈0.05）;6 min walking distance than before treatment increased,the difference was statistically significant（P〈0.05）.Conclusion Sildenafil improves pulmonary hypertension patients with heart function and respiratory difficulties,significantly improved exercise capacity,and pulmonary arterial pressures also have decreased,and the side effect is small,is a selection of safe and effective drugs.
出处
《中国药物经济学》
2016年第7期85-87,共3页
China Journal of Pharmaceutical Economics
关键词
西地那非
肺动脉高压
效果
安全性
Sildenafil
Pulmonary arterial hypertension
Effect
Security
