摘要
目的分析重症心肌炎患者应用丙种球蛋白治疗的疗效，以及丙种球蛋白对患者心肌损伤及心功能的影响。方法根据随机数字表法将2010年9月～2015年9月陕西省宝鸡市中医医院心血管内二科收治的40例急性重症心肌炎患者平均分为对照组和观察组，每组20例，对照组患者给予常规综合治疗，观察组患者另外应用丙种球蛋白进行静脉注射，对两组患者临床治疗效果、治疗前后的左心室内径（LV）、左心室射血分数（LVEF）、心肌肌钙蛋白（cTnT）、肌酸激酶同工酶（CK—MB）和B型脑钠肽（BNP）的改善情况进行比较。结果观察组患者治疗后的临床总有效率和对照组比较明显较高（P〈0．05）。在LV、LVEF方面，两组患者在治疗前及治疗2周后的数值比较差异无统计学意义（P〉0．05）；观察组患者治疗1个月后的LV平均值与对照组比较明显降低（P〈0．05），LVEF值和对照组比较明显升高（P〈0．05）。治疗1个月后。两组患者治疗的各项水平均显著低于治疗前水平，观察组患者各项水平的降低程度显著高于对照组患者（P〈0．05）。结论丙种球蛋白治疗重症心肌炎的临床效果较好，可以有效改善心功能和心肌损伤指标，建议推广应用。
Objective To analyse the clinical effect and impact on myocardial damage and heart function of patients with severe myocarditis by using the treatment of gamma globulin. Methods 40 cases of patients with acute severe myocarditis in the Department of Second Division of Cardiovascular of Baoji City Chinese Medicine Hospital were extracted from September 2010 to September 2015. All patients were randomly divided .into observation group and control group, with 20 cases in each group. The patients in the control group were treated with routine comprehensive treatment, while those in the observation group received gamma globulin for intravenous injection. The clinical effect and improvement situation of left ventricular diameter （LV）, left ventricular ejection fraction （LVEF）, cardiac troponin T （cTnT）, creatine kinase isoenzyme （CK-MB）, and B type natriuretic peptide （BNP） before and after treatment were compared between the two groups. Results The to.tal effective rate in the observation group was significantly higher than that in the control group （P 〈 0.05）. There were no significant differences in the LV and LVEF before and after 2 weeks of treatment （P〉 0.05）. The LV mean value after 1 months of treatment in the observation group was significantly lower than that in the control group, while the LVEF value was significantly higher than that in the control group （P 〈 0.05）. After 1 month of treatment, all levels of the two groups were significantly lower than those before treatment, while the levels in the observation group decreased significantly （P 〈 0.05）. Coulusion Gamma globulin treatment has good clinical effect of patients with severe myocarditis, which can effectively improve the cardiac function and myocardial injury index. It is worthy of wide clinical application.
出处
《中国医药导报》
CAS
2016年第22期61-64,68,共5页
China Medical Herald
关键词
重症心肌炎
丙种球蛋白
LV
LVEF
CTNT
CK—MB
BNP
Severe myocarditis
Gamma globulin
Left ventricular diameter
Left ventricular ejection fraction
Cardiac troponin T
Creatine kinase isoenzyme
B type natriuretic peptide
