摘要
目的探讨前列地尔联合坎地沙坦对2型糖尿病肾病住院患者肾功能的影响。方法选取2015年至2016年于青岛内分泌糖尿病医院住院的2型糖尿病患者60例,随机分为坎地沙坦联合前列地尔组30例(试验组)和坎地沙坦组30例(对照组),试验组给予坎地沙坦8mg每日1次联合前列地尔10μg每日1次,对照组给予单纯坎地沙坦8mg每日1次治疗,治疗疗程均为2周,观察用药前后血肌酐、尿素氮、24h尿微量白蛋白、肾小球滤过率等变化。结果与坎地沙坦组相比,联合用药组24h尿微量白蛋白、血肌酐、尿素氮水平明显下降(P<0.05),肾小球滤过率明显升高(P<0.05)。结论前列地尔联合坎地沙坦较单纯坎地沙坦可更好保护肾功能,延缓肾功能恶化。
Objective To observe the clinical effect of alprostadil combined candesartan for treatmentof early-stage diabetic nephropathy. Methods A total of 60 patients with type 2 diabeticnephropathy admitted to Qingdao Endocrine and Diabetes Hospital from 2015 to 2016 were selected,and were divided into experiment group and control group randomly, with 30 cases in eachgroup. Experiment group was given alprostadil （ lOyg once a day） combined candesartan （8mgonce a day） for treatment while control group was given candesartan（8mg once a day） for treatment.Two weeks were set as one treatment course. Serum creatinine（SCR）,blood urea nitrogen（BUN） ,24h microalbumin（24h-ALB） and glomerular filtration rate（GFR） were observed beforeand after the treatment. Results Compared with candesartan group, alprostadil combined candesartangroup showed apparent decline of SCR,BUN？24h-ALB and increase of GFR（P 〈C0. 05）.Conclusion Alprostadil combined candesartan has much better effect on the treatment of diabeticnephropathy than candesartan group.
出处
《青岛医药卫生》
2016年第4期253-255,共3页
Qingdao Medical Journal
