摘要
目的了解老年患者临床分离鲍曼不动杆菌的分布及其对常用抗生素的耐药状况,为临床医师合理使用抗菌药物提供依据。方法对2011年1月—2013年12月146例老年住院患者中检出的146株鲍曼不动杆菌就标本来源、临床分布及耐药性进行统计学分析。结果 146株鲍曼不动杆菌以痰标本为主(占83.6%),其次为创口引流液(占7.5%);感染科室分布以呼吸内科、中医科为主,分别占52.7%、17.1%;对头孢他啶、头孢噻肟、哌拉西林和头孢吡肟4种抗菌药物耐药率大于70%,其中对头孢他啶、头孢噻肟的耐药率分别为93.8%、93.6%;对亚胺培南的耐药率为30.1%;对阿米卡星耐药率最低,为27.4%;检出45株鲍曼不动杆菌为多重耐药菌株(占30.8%);结论老年患者鲍曼不动杆菌对多种抗菌药物的耐药情况严重,应加强对鲍曼不动杆菌耐药性的监测,合理使用抗菌药物,遏制耐药菌株的传播流行。
Objective To understand the prevalence and resistance profile of Acinetobacter baumannii isolated from geriatric patients for better use of antimicrobial agents. Methods A total of 146 patients with A, baumannii were identified from January 2011 to December 2013 in our hospital. The resistance ofA. baumannii isolates to antibiotics were analyzed. Results The 146 isolates were mostly isolated from sputum （83.6%） and wound secretion （7.5%）. The cases were mainly found in Department of Respiratory Medicine and Traditional Chinese Medicine （52.7% and 17.1%, respectively）. More than 70% of the isolates were resistant to four antibiotics, including ceftazidime （93.8%） and cefotaxime （93.6%）. The strains showed the lowest resistance rate to imipenem （30.1%） and amikacin （27.4%）. Multi-drug resistance was identified in 45 （30.8%） of the A. baumannii strains. Conclusions A. baumannii is an important pathogen contributing to nosocomial infections in geriatric patients, which is associated with high-level resistance to multiple antibiotics. The prevalence and resistance profile of A. baumannii should be monitored for better antimicrobial therapy and control of outbreak ofA. baumannii infection.
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2016年第1期54-56,共3页
Chinese Journal of Infection and Chemotherapy
关键词
鲍曼不动杆菌
老年患者
耐药性
Acinetobacter baumannii
geriatric inpatient
antibiotic resistance
