摘要
氧气吸入是治疗一些疾病的重要手段,尤其可改善新生儿缺氧状态。但长时间的高氧治疗会对机体器官产生严重的毒性作用。高氧能诱发线粒体产生活性氧(reactive oxygen species,ROS)进而引起器官损伤。高氧环境中肠上皮细胞遭到破坏时伴随着ROS的增加,激活NF-κB信号通路,进而引起一系列的炎症反应,因此,ROS在高氧肠道损伤中发挥着重要作用。
Oxygen is an important way for the treatment of some diseases,especially to improve newborn hypoxia state. But high oxygen treatment for a long time could have serious toxic effect on the body＇s organs. Hyperoxia can induce mitochondria produce reactive oxygen species（ ROS） and cause organ damage. Hyperoxia＇s environment in intestinal epithelial cells were destroyed along with the increase of ROS,activity of the NF-κB signaling pathways,resulting in a series of inflammation,thus ROS plays an important role in hyperoxia intestinal injury.
出处
《胃肠病学和肝病学杂志》
CAS
2016年第8期948-951,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
国家自然科学基金(30871158
81170604)
盛京自由研究者
