摘要
既往研究显示精神分裂症患者言语性幻听症状存在特异的脑结构网络损害、脑功能网络紊乱、脑血流和脑神经代谢物紊乱,这些研究在很大程度上增进了对言语性幻听症状神经病理机制的理解。然而,言语性幻听症状相关的特异性脑影像学表征是否随时间或病程进展而演变?脑影像学表征(脑网络、脑血流)的发展轨迹呈何特征?治疗结局不同的患者之间是否存在不同的基线特异性脑影像学表征,哪些特异的基线脑影像学表征能够预测疗效结局,为个体化精准治疗方案的制定提供客观依据?这些问题尚需通过进一步的深入研究来揭示。因此,采用多模态磁共振成像技术,从多角度纵向分析首发精神分裂症患者言语性幻听症状的脑影像学指标演变轨迹及其与疗效结局之间的关系,将有助于阐释上述问题。
Previous studies reported that schizophrenia patients with auditory verbal hallucinations（AVHs） demonstrated structural network impairment,functional network disturbance,cerebral blood disturbance and neural metabolism disturbance.The findings of aforementioned studies enhanced our understanding about the pathological mechanisms of AVHs.However,if the brain imaging characters which related to the AVHs symptom will development following the time or illness duration？ How the dynamically developmental trajectories of brain imaging characters which related to the AVHs symptom will be demonstrated？ which relationship between the brain iamging characters and the therapeutic effects and outcomes will be demonstrated？ Which brain imaging characters can predict the therapeutic effects and provide objective indices to help the precision treatment？ To achieve this aim,we must conduct a longitudinal study which adopt multimodality techniques,recruiting the first-episode schizophrenia patients with AVHs,analyze the dynamically developmental trajectories of the brain imaging characters related to AVHs from multiple perspectives and the relationship between the brain characters and therapeutic outcomes will help us to explain above mentioned questions.
出处
《中华诊断学电子杂志》
2016年第2期100-103,共4页
Chinese Journal of Diagnostics(Electronic Edition)
关键词
言语性幻听
精神分裂症
磁共振成像
Auditory verbal hallucinations
Schizophrenia
Magnetic resonance imaging
