摘要
目的观察自研中药方治疗痰浊血瘀型早发冠心病的临床疗效。方法选取2014年1月—2016年1月在邯郸市第一医院和邯郸市中心医院心内科住院治疗的痰浊血瘀型早发冠心病患者150例,采用随机数字表法分为对照组74例和治疗组76例。两组患者均给予常规治疗,对照组患者在常规治疗基础上加用安慰剂治疗,治疗组患者在常规治疗基础上加用自研中药方治疗;2周为1个疗程,两组患者均连续治疗2个疗程。比较两组患者心绞痛疗效及心电图疗效、治疗前后血脂指标〔三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕及中医症候(胸闷、胸痛、胸闷胸痛持续时间、胸闷胸痛发作频率、气促、疲乏、心悸、自汗)评分,并观察两组患者治疗期间不良反应发生情况。结果治疗组患者心绞痛疗效及心电图疗效均优于对照组(P<0.05)。治疗前两组患者TG、TC、HDL-C、LDL-C水平比较,差异无统计学意义(P>0.05);治疗后,治疗组患者TG、TC、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05)。治疗前两组患者胸闷、胸痛、胸闷胸痛持续时间、胸闷胸痛发作频率、气促、疲乏、心悸、自汗评分及总分比较,差异无统计学意义(P>0.05);治疗后,治疗组患者胸闷、胸痛、胸闷胸痛持续时间、胸闷胸痛发作频率、气促、疲乏、心悸、自汗评分及总分均低于对照组(P<0.05)。治疗期间,对照组患者出现恶心、呕吐2例,治疗组患者出现肠胃不适3例。结论自研中药方治疗痰浊血瘀型早发冠心病的临床疗效确切,可有效改善患者血脂代谢及胸闷、胸痛等症状,且不良反应少。
Objective To observe the clinical effect of self - made traditional prescription on premature coronary heart disease diagnosed as TCM syndrome of phlegm turbidity and blood stasis. Methods From January 2014 to January 2016,a total of 150 premature coronary heart disease patients diagnosed as TCM syndrome of phlegm turbidity and blood stasis were selected in the Department of Cardiology,the First Hospital of Handan,in the Department of Cardiology,the Central Hospital of Handan, and they were divided into control group(n = 74)and treatment group(n = 76)according to random number table. Based on conventional treatment,patients of control group were given placebo,while patients of treatment group were given self - made traditional prescription;both groups continuously treated for two courses(2 weeks as a course). Curative effects of angina pectoris and electrocardiogram,blood lipids index(including TG,TC,HDL-C and LDL-C)and traditional clinical symptoms (including chest distress,chest pain,duration and attack frequency of chest distress/ chest pain,shortness of breath,fatigue, palpitation and spontaneous perspiration)score before and after treatment were compared between the two groups,and incidence of adverse reactions during the treatment was observed. Results The curative effects of angina pectoris and electrocardiogram of treatment group were statistically significantly better than those of control group ( P < 0. 05 ). No statistically significantly differences of TG,TC,HDL-C or LDL-C was found between the two groups before treatment(P > 0. 05);after treatment,TG, TC and LDL-C of treatment group were statistically significantly lower than those of control group,while HDL-C of treatment group was statistically significantly higher than that of control group(P < 0. 05). No statistically significant differences of chest distress score,chest pain score,duration of chest distress/ chest pain score,attack frequency of chest distress/ chest pain score, shortness of breath score,fatigue score,palpitation score,spontaneous perspiration score or total score was found between the two groups before treatment( P > 0. 05),while chest distress score,chest pain score,duration of chest distress/ chest pain score,attack frequency of chest distress/ chest pain score, shortness of breath score, fatigue score, palpitation score, spontaneous perspiration score and total score of treatment group were statistically significantly lower than those of control group after treatment(P < 0. 05). During the treatment,two cases of control group occurred nausea and vomiting,three cases of treatment group occurred gastrointestinal discomfort. Conclusion Self - made traditional prescription has certain clinical effect in treating premature coronary heart disease diagnosed as TCM syndrome of phlegm turbidity and blood stasis,can effectively adjust the blood lipid metabolism and relieve the chest distress/ chest pain,with less adverse reactions.
出处
《实用心脑肺血管病杂志》
2016年第8期92-95,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
河北省科学技术厅资助项目(132777101D)
关键词
冠心病
心绞痛
血瘀
中药方剂学
随机对照试验
Coronary disease
Angina pectoris
Blood stasis
Science of prescription(TCD)
Randomized controlled trial
