摘要
目的探讨多囊卵巢综合征(PCOS)临床干预前后血清内脂素水平变化及其在PCOS病理生理机制中的作用。方法选择治疗的73例PCOS患者作为观察组,选择同期体检的健康人55例作为对照组,比较两组治疗前后血清内脂素水平变化及其相关因素,同时对观察组治疗前后患者机体血清内脂素水平、睾酮(T)水平、体质指数(BMI)、促黄体生成素(LH)/促卵泡生成素(FSH)及胰岛素抵抗指数(HOMA-IR)水平的变化情况。结果观察组BMT、T及LH/FSH指标水平显著高于对照组,差异有统计学意义(P<0.05);观察组中内脂素水平与HOMA-IR呈现低正相关(r=0.415,P<0.01),BMI与HOMA-IR呈现中正相关性(r=0.647,P<0.01),T与LH/FSH呈现中正相关性(r=0.623,P<0.01);观察组治疗后BMT、T、LH/FSH及HOMA-IR水平显著低于治疗前,比较差异有统计学意义(P<0.05),而血清内脂素水平显著高于治疗前,差异亦有统计学意义(P<0.05);治疗后BMI与HOMA-IR呈低正相关性(r=0.395,P<0.05),T与LH/FSH水平呈低正相关性(r=0.413,P<0.05)。结论 PCOS患者体内血清内脂素水平与正常健康人无显著性差异,且在对PCOS患者进行干预治疗后血清内脂素水平有所升高,提示血清内脂素在PCOS患者各项其他指标的纠正性治疗中有一定的积极意义。
Objective To investigate the changes of serum lipid levels of polycystic ovary syndrome （PCOS） before and after clinical intervention and its role of in the pathophysiology. Methods 73 cases of PCOS patients were selected as the observation group, 55 cases of patients with the physical examination in the hospital during the same period were selected as control group. Serum visfatin level and its related factors of the two groups were compared, and body lignans, level of serum testosterone （T） levels, body mass index （BMI） , luteinizing prime （LH） /Pro follicle stimulating hormone （FSH） and insulin resistance index （HOMA - IR） level changes in the observation group before and after treatment were observed. Results BMT, T and LH/FSH index in the observation group were significantly better than those of the control group, the difference was statistically significant （ P 〈0 . 05）. The visfatin levels and HOMA - IR in the observation group showed low positive correlation （ r = 0.415 , P 〈0.01）. BMI and HOMA - IR showed positive correlation （ r = 0. 647 , P 〈 0 . 01）. T and LH / F S H showed positive correlation （ r = 0.623 , P 〈0. 01）. BMT, T, LH/FSH and HOMA - IR levels of the observation group after treatment were significantly lower than those before treatment, the difference was statistically significant （ P 〈 0 . 0 5 ） , and the serum visfatin level was significantly higher than that before treatment, there were significant differences （ P 〈 0 . 05）. After treatment, BMI and HOMA - IR had low positive correlation （ r = 0. 395 , P 〈 0. 05 ）. T and LH/FSH showed a low positive correlation （ r =0.413, P 〈 0 . 0 5 ） . Conclusion Serum lignans level in PCOS patients has no significant difference with normal healthy people. After the intervention therapy, the serum visfatin level increased, suggesting that serum lipid pigment in the correct treatment of the body of the other indicators have certain positive significance.
出处
《临床和实验医学杂志》
2016年第18期1830-1832,共3页
Journal of Clinical and Experimental Medicine
