摘要
东方田鼠是重要的实验动物资源之一,本文总结了本实验室过去十几年来对东方田鼠进行的实验动物化工作,包括生物学性状、建群者与群体的有效大小、驯养、驯化(实验动物化)及进化动力等方面的研究以及实验动物化结果的评估和地方标准的制定。展望了以新一代基因组测序技术为基础进行的抗性基因的寻找与新品系的精细培育新方法的摸索。
Microtus fortis is one of the important resources as laboratory animal. In this review we summarized the work of breeding this animal from wild as laboratory animal in over the past ten years,the researches including of biological characteristics; the founder and effective size of the population; tameness and domestication（ breeding as laboratory animal） as well as the evolutionary force in this process. It was described that evaluation results of breeding as laboratory animal and formulation of local standard of this vole. New technology in finding the vole resistance gene of Schistosoma japonicum and new method of breeding strains will be expected under next-generation sequencing technique.
出处
《实验动物科学》
2016年第3期32-36,共5页
Laboratory Animal Science
基金
湖南省科研条件创新专项(No.2013TT2004)
湖南省科技重点研发计划(No.2015DK3008)
湖南省卫计委科研计划(No.B2015-1)
关键词
东方田鼠
实验动物化
地方标准
Microtus fortis
breeding as laboratory animal
local standard
