摘要
目的探讨脓毒症患儿并发脓毒症相关性脑病（sepsis associated encephalopathy，SAE）的危险因素及其与预后的关系。方法收集2013年6月至2015年4月深圳市儿童医院PICU收治的152例脓毒症患儿的临床资料，根据患儿是否合并SAE分为SAE组（n=46）和非SAE组（n=106）。采用单因素分析和多因素Logistic回归分析方法，分析儿童SAE发生及死亡的危险因素。结果152例脓毒症患儿中，合并SAE46例，发病率30．3％，合并SAE患儿的病死率（8／46，17．4％）显著高于无SAE患儿的病死率（2／106，1．9％）（r=13．234，P〈0．001）。其中凝血功能障碍、肝功能不全，小儿危重病例评分≤80分是SAE发生的独立危险因素，凝血功能障碍是SAE死亡的独立危险因素。结论SAE的发病率及病死率高，对凝血功能障碍、肝功能不全和小儿危重病例评分≤80分的患儿需严密监测。
Objective To investigate the risk factors of sepsis associated encephalopathy （SAE） in children. Methods We collected the clinical data of 152 cases of children with sepsis admitted in PICU of Shenzhen Children＇s Hospital from June 2013 to April 2015. All 152 cases were divided into the SAE group （n =46） and non SAE group（ n = 106）. Single factor analysis and multi-factor Logistic regression analysis were used to study the risk factors of the occurrence and mortality of SAE in children. Results The inci- dence of SAE was 30.3 % among sepsis. The mortality rate of children with SAE was obviously higher than that of children without SAE（ 17.4% ,8/46 vs. 1.9% ,2/106;χ2 = 13. 234,P 〈 0. 001 ）. Logistic regression analysis showed that coagulation disorder,hepatic insufficiency and pediatric clinical illness score ~〈80 were independent risk factors of SAE. Coagulation disorder was independent risk factors of SAE death. Conclusion The incidence and mortality of SAE are high. Children with coagulation disorder, hepatic insufficiency and pediatric clinical illness score ≤ 80 should be observed closely.
出处
《中国小儿急救医学》
CAS
2016年第8期543-546,共4页
Chinese Pediatric Emergency Medicine
关键词
脓毒症相关性脑病
危险因素
儿童
Sepsis associated encephalopathy
Risk factor
Children
