摘要
目的探索周平安教授治疗外感发热的中药配伍及组方用药规律。方法筛选整理周平安教授治疗外感发热医案,对所用药物通过SPSS 21.0和SPSS Modeler 18.0进行药物及其性味归经频数分析、关联规则分析及聚类分析。结果 (1)药物及其性味归经频数分析总结出解表药、清热药、宣肺止咳药位居前三位;苦寒与辛温之品并用,但以苦寒清热为主;以归属肺经药物为主,直达病所,兼顾脾胃,或清泄大肠,表里同治。(2)关联规则分析提取出柴胡、黄芩,炙麻黄、杏仁两组常用药对及解表药→柴胡+黄芩、解表药→炙麻黄+杏仁两组常见的配伍组合。(3)聚类分析得出柴胡、黄芩,炙麻黄、杏仁、生石膏、生甘草,羌活、紫苏叶、荆芥、薄荷,金银花、连翘,射干、桔梗,豆豉、青蒿、生黄芪等9组药。结论周平安教授在治疗外感发热时几个用药特点:(1)苦寒辛温并用,以苦寒清热为主;(2)解表清里,清透兼施;(3)脏腑同治,照顾兼证。
Objective To explore the patterns of the composition and prescription of traditional Chinese medicine（ TCM） of professor ZHOU Ping-an in the treatment of externally contracted fever. Methods The medical records of professor ZHOU Ping-an used for treating externally contracted fever were filtered and reorganized,frequency analysis,association rule analysis and cluster analysis were used to analyse flavor and channel tropism of the herbs prescribed,the analysis software were SPSS 21. 0 and SPSS Modeler 18. 0. Results（ 1） Frequency analysis showed that exterior-resolving,heat-clearing and lung-facilitating and cough-relieving herbs were at the top three of most commonly used types of TCM; cold and bitter with warm and acrid types of TCM were combined,while cold and bitter type dominated to clear heat;herbs affiliated to lung channel were used frequently to guide medications directly to the illness location,while covering spleen and stomach,or dissipating and clearing large intestine to cure both exterior and interior.（ 2） Association rule analysis extracted two frequently used pairs of herbs,which are bupleurum scutellaria,mix-frying ephedra apricot kernel,as well as two frequently used compositions of herbs,respectively bupleurum scutellaria for exterior-resolving and mix-frying ephedra apricot kernel for exteri-or-resolving.（ 3） Cluster analysis obtained nine clusters of herbs： bupleurum scutellaria,mix-frying ephedra apricot kernel crude gypsum raw licorice,notopterygium perilla schizonepeta mint,lonicera forsythia,belamcanda platycodon,fermented soybean sweet wormwood crude astragalus,etc. Conclusions There are three main characteristics of the composition and prescription of TCM of professor ZHOU Ping-an in the treatment of externally contracted fever：（ 1） Combining cold and bitter with warm and acrid types of TCM,while cold and bitter type dominates to clear heat;（ 2） resolving exterior as well as clearing interior,clearing heat and expelling toxins simultaneously;（ 3） aiming at lungs and large intestine at the same time,while covering accompanying symptoms.
出处
《环球中医药》
CAS
2016年第9期1038-1043,共6页
Global Traditional Chinese Medicine
基金
国家科技支撑计划名老中医特色治法治则传承研究(2013BAI13B021)
北京市中医管理局薪火传承周平安名医工作站建设项目
北京中医药大学科研创新团队项目(2011-CXTD-08)
关键词
周平安
外感发热
数据挖掘
用药规律
ZHOU Ping-an
Externally contracted fever
Data mining
Prescription patterns
