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MR定量磁敏感图评估正常人大脑静脉血氧饱和度的初步研究 被引量:4

Preliminary study of cerebral venous oxygen saturation in healthy people using MR quantitative susceptibility mapping
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摘要 目的:通过MR定量磁敏感图(QSM)测量脑静脉的磁敏感值,评价正常人脑静脉血氧饱和度有无性别、侧别的差异及与年龄的相关性。方法2012年11月至2014年9月收集60名健康右利手志愿者行常规MRI和磁敏感加权成像(SWI)扫描,获得正常颅脑相位图和幅度图。利用磁敏感图像成像与相位伪影消障工具(SMART)后处理软件对相位图和幅度图进行处理得到QSM,利用核磁共振信号处理(SPIN)软件手工绘出磁敏感图中双侧大脑静脉(大脑皮层静脉、丘脑纹状体静脉、透明隔静脉、大脑内静脉、基底静脉)的ROI,测量不同静脉的磁敏感值。采用秩和检验比较不同侧别和性别间大脑静脉磁敏感值的差异。利用Spearman相关分析其与年龄的相关性。结果60名健康志愿者左右两侧大脑皮层静脉磁敏感值中位数(范围)分别为159.16(154.88~164.13)ppb(×10-9)、164.61(156.23~168.04)ppb,丘脑纹状体静脉相应值分别为160.51(152.14~170.06)ppb、162.48(153.47~173.66)ppb,左侧均小于右侧,差异具有统计学意义(Z值分别为-3.14、-2.02,P值均〈0.05)。其他部位大脑静脉左右两侧敏感值差异无统计学意义。22名男性健康志愿者右侧大脑皮层静脉、左侧丘脑纹状体静脉、右侧透明隔静脉磁敏感值分别为166.22(159.21~169.99)ppb、168.65(159.19~174.45) ppb、153.42(148.10~161.78)ppb,38名女性相应部位磁敏感值分别为161.10(155.06~167.15)ppb、157.70(151.53~164.41)ppb、147.52(142.94~154.16)ppb,男性与女性间差异具有统计学意义(Z值分别为-2.03、-2.20、-2.33,P值均〈0.05)。右侧丘脑纹状体静脉的磁敏感值与年龄具有相关性(r=0.28, P〈0.05)。结论右侧丘脑纹状体静脉磁敏感值随年龄改变有增加的趋势,部分大脑静脉磁敏感值存在侧别和性别差异。 of left and right side cerebral cortical veins was 159.16(154.88-164.13)ppb(× 10-9), 164.61(156.23-168.04) ppb, respectively. The median susceptibility (extent) of left and right side thalamostriate veins was 160.51 (152.14-170.06) ppb, 162.48(153.47-173.66)ppb, respectively. Left were less than the right, and the difference was statistically significant (Z=-3.14,-2.02, P〈0.05). And the difference of two side of other cerebral venous susceptibility had no statistical significance. The median susceptibility (extent) of right cerebral cortical veins, left thalamostriate veins and right septal veins of 22 male was 166.22(159.21-169.99) ppb, 168.65(159.19-174.45)ppb and 153.42(148.10-161.78)ppb, respectively. The coresponding positions of median susceptibility (extent) of 38 female was 161.10(155.06-167.15)ppb, 157.70(151.53-164.41)ppb and 147.52(142.94- 154.16)ppb, respectively. The susceptibility of right cerebral cortical vein, left thalamostriate vein, right septal vein of male was significantly different from the females (Z=-2.03,-2.20,-2.33, P〈0.05). Futhermore, we also found that there had positive correlation between age and right thalamostriate vein(r=0.28,P〈0.05). Conclusion The magnetic sensitive of the right thalamostriate vein tends to increase along with the age, and some of peoples had difference with bilateral and age.
出处 《中华放射学杂志》 CAS CSCD 北大核心 2016年第9期652-656,共5页 Chinese Journal of Radiology
基金 国家自然科学基金(81501457) 天津市卫生局重点攻关基金(14KG103)
关键词 脑静脉 磁共振成像 年龄因素 Cerebral veins Magnetic resonance imaging Age factors
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