摘要
目的了解米非司酮紧急避孕失败而又自愿生育者，其所用药物对妊娠及胎儿是否有不良影响。方法选取服用米非司酮紧急避孕失败继续妊娠的孕妇100例为研究组，正常妊娠无药物流产史及引产史的孕妇100例作为对照组，分别在孕13～15周、孕24周和分娩后，用B超作胎儿生长发育监测和胎儿畸形筛查。结果研究组自然流产13例（13．0％），对照组1例（1．0％），研究组自然流产率高于对照组，差异有统计学意义（P〈0．01）。研究组胎儿畸形3例（3．0％），新生儿畸形3例（3．0％），对照组发现胎儿畸形2例（2．0％），新生儿畸形2例（2．0％），差异无统计学意义（P〉0．05）。研究组新生儿窒息9例（9．0％），对照组新生儿窒息1例（1．0％），差异有统计学意义（P〈0．05）。结论米非司酮紧急避孕失败患者自然流产率、新生儿窒息发生率高于正常人群，要积极预防。
Objective To explore the effect of mifepristone on the primiparas and neonates after the failure of emergency contraception. Methods One hundred primiparas who took mifepristone for emergency contraception but failed were collected as the study group, and other 100 primiparas without the history of taking abortifacient pills as the control group. The inspections for fetal growth and fetal malformation were conducted by ultrasound at 13 - 15 weeks, 24 weeks of gestation and after delivery respectively, and the results were compared between the two groups. Results The spontao.e.ous miscarriage rate of the study group（ 13.0% ） was significantly lower than that of the con- trol group（ 1.0% ） , P〈0.01. There were no significant differences in fetal malformation and neonatal malformations between the study group and the control group（3.0% vs 2. 0% and 3.0% vs 2.0% ） , P 〉0. 05. The rate of neo- natal asphyxia in the study＇group was significantly higher than that in the control group, P 〈 0.05. Conclusion The pregnant women taking mifepristone for emergency contraception but failing to abort the fetus have higher spontaneous abortion rate and neonatal asphyxia rate than the normal pregnant women.
出处
《中国临床新医学》
2016年第9期782-784,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
广西卫计委科研课题(编号:Z2008044)
关键词
米非司酮
紧急避孕失败
胎儿
新生儿
Mifepristone
Emergency contraceptive failure
Fetus
Neonate
